Evidence map›Paper›PMID 25682593›Full record

ReviewArchivum immunologiae et therapiae experimentalis2015

Human Microbiome: When a Friend Becomes an Enemy.

Magdalena Muszer, Magdalena Noszczyńska, Katarzyna Kasperkiewicz, Mikael Skurnik

Registry-linked trialAbstract readReview
In one paragraph

Review in Archivum immunologiae et therapiae experimentalis, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05196061 (Human Skin and Gut Mycobiome and Bacteriome Comprehensive Registry), which is not on this map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05196061 recruitingnot on this mapstarted 2020, after this paper: background citation

Human Skin and Gut Mycobiome and Bacteriome Comprehensive Registry

Typeobservational_patient_registrySponsorUniversity Hospitals Cleveland Medical CenterRan2020 to 2030Enrolled5,000ConditionsHealthy VolunteersArmsQuestionnaire, Stool sample, Skin swab, Oral rinse
3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Do Gut Microbes Taste?Nutrients · 2021
    Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Interleukin-22 and Its Correlation with Disease Activity in Plaque Psoriasis.Archivum immunologiae et therapiae experimentalis · 2019
    Article
  17. Review
  18. Pollution and acne: is there a link?Clinical, cosmetic and investigational dermatology · 2017
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Magdalena MuszerDepartment of Microbiology, University of Silesia, Katowice, Poland.
Magdalena Noszczyńska
Katarzyna Kasperkiewicz
Mikael Skurnik

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The microorganisms that inhabit humans are very diverse on different body sites and tracts. Each specific niche contains a unique composition of the microorganisms that are important for a balanced human physiology. Microbial cells outnumber human cells by tenfold and they function as an invisible organ that is called the microbiome. Excessive use of antibiotics and unhealthy diets pose a serious danger to the composition of the microbiome. An imbalance in the microbial community may cause pathological conditions of the digestive system such as obesity, cancer and inflammatory bowel disease; of the skin such as atopic dermatitis, psoriasis and acne and of the cardiovascular system such as atherosclerosis. An unbalanced microbiome has also been associated with neurodevelopmental disorders such as autism and multiple sclerosis. While the microbiome has a strong impact on the development of the host immune system, it is suspected that it can also be the cause of certain autoimmune diseases, including diabetes or rheumatoid arthritis. Despite the enormous progress in the field, the interactions between the human body and its microbiome still remain largely unknown. A better characterization of the interactions may allow for a deeper understanding of human disease states and help to elucidate a possible association between the composition of the microbiome and certain pathologies. This review focuses on general findings that are related to the area and provides no detailed information about the case of study. The aim is to give some initial insight on the studies of the microbiome and its connection with human health.

Indexed as

MicrobiotaAcne VulgarisArthritis, RheumatoidAtherosclerosisAutistic DisorderDermatitis, AtopicDiabetes Mellitus, Type 1Gastrointestinal NeoplasmsHomeostasisHumansImmune SystemInflammatory Bowel DiseasesMultiple SclerosisObesityPsoriasisSkin

Identifiers

PMID25682593
PMCPMC4499106

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.