ArticleDrug and alcohol dependence2015
Resting-state regional cerebral blood flow during adolescence: associations with initiation of substance use and prediction of future use disorders.
Article in Drug and alcohol dependence, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 22 citations in OpenAlex.
- Adolescent alcohol consumption predicted by differences in electrophysiological functional connectivity and neuroanatomy.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Adolescent Neurodevelopment Within the Context of Impulsivity and Substance Use.Current addiction reports · 2023Article
- Promising vulnerability markers of substance use and misuse: A review of human neurobehavioral studies.Neuropharmacology · 2021Review
- Interactions between monoamine oxidase A rs1137070 and smoking on brain structure and function in male smokers.The European journal of neuroscience · 2019Article
- The role of familial risk, parental psychopathology, and stress for first-onset depression during adolescence.Journal of affective disorders · 2019Article
- Trajectories of Alcohol Initiation and Use During Adolescence: The Role of Stress and Amygdala Reactivity.Journal of the American Academy of Child and Adolescent Psychiatry · 2018Article
- Research Review: What have we learned about adolescent substance use?Journal of child psychology and psychiatry, and allied disciplines · 2018Review
- Neurobiology of substance use in adolescents and potential therapeutic effects of exercise for prevention and treatment of substance use disorders.Birth defects research · 2017Review
- Adolescence and Drug Use Vulnerability: Findings from Neuroimaging.Current opinion in behavioral sciences · 2017Article
- Risk factors and global cognitive status related to brain arteriolosclerosis in elderly individuals.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2017Article
- Neurobiological signatures associated with alcohol and drug use in the human adolescent brain.Neuroscience and biobehavioral reviews · 2016Review
- Alcohol and Drug Use and the Developing Brain.Current psychiatry reports · 2016Review
- Neurodevelopmental Precursors and Consequences of Substance Use during Adolescence: Promises and Pitfalls of Longitudinal Neuroimaging Strategies.Frontiers in human neuroscience · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundAdolescence is a period of developmental flux when brain systems are vulnerable to influences of early substance use, which in turn relays increased risk for substance use disorders. Our study intent was to assess adolescent regional cerebral blood flow (rCBF) as it relates to current and future alcohol use. The aim was to identify brain-based predictors for initiation of alcohol use and onset of future substance use disorders.
methodsQuantitative rCBF was assessed in 100 adolescents (age 12-15). Prospective behavioral assessments were conducted annually over a three-year follow-up period to characterize onset of alcohol initiation, future drinking patterns and use disorders. Comparisons amongst use groups (i.e., current-, future-, and non-alcohol using adolescents) identified rCBF associated with initiation of alcohol use. Regression by future drinking patterns identified rCBF predictive of heavier drinking. Survival analysis determined whether or not baseline rCBF predicted later development of use disorders.
resultsBaseline rCBF was decreased to the parietal cortex and increased to mesolimbic regions in adolescents currently using alcohol as well as those who would use alcohol in the future. Higher baseline rCBF to the left fusiform gyrus and lower rCBF to the right inferior parietal cortex and left cerebellum was associated with future drinking patterns as well as predicted the onset of alcohol and substance use disorders in this cohort.
conclusionsVariations in resting rCBF to regions within reward and default mode or control networks appear to represent trait markers of alcohol use initiation and are predictive of future development of use disorders.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.