ArticleSurgery today2016
Sclerotherapy with bleomycin versus surgical excision for extracervical cystic lymphatic malformations in children.
Article in Surgery today, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06943703 (Safety, Efficacy, and Long-Term Outcomes of Intralesional Bleomycin Injection as an Adjunctive Therapy for Pediatric Lymphatic Malformations), which is not on this map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Safety, Efficacy, and Long-Term Outcomes of Intralesional Bleomycin Injection as an Adjunctive Therapy for Pediatric Lymphatic Malformations: A Retrospective Study on Cosmetic and Health-Related Quality of Life Improvements.
Who cites it
11 citing papers in PubMed, 25 citations in OpenAlex.
- Mediastinal Lymphangioma of the Adult: Case Report and Literature Review.Clinics and practice · 2026Article
- A neonate in emergency for giant auricular and cervical lymphatic malformations: Ultrasound-guided percutaneous bleomycin sclerotherapy may be a choice.Pediatric investigation · 2024Article
- Article
- Intralesional bleomycin injection treatment of intra-abdominal lymphangiomas presenting with acute abdomen in children.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2023Article
- Case report and literature review: Giant retroperitoneal cystic lymphangioma.Frontiers in surgery · 2023Article
- Cervical lymphangioma in adults: A report of seven cases and review of the literature.Laryngoscope investigative otolaryngology · 2022Article
- Lymphatic malformations in children: treatment outcomes of sclerotherapy in a large cohort.European journal of pediatrics · 2021Article
- Recent Progress in Lymphangioma.Frontiers in pediatrics · 2021Review
- Inflow Occlusion Combined With Bleomycin Sclerotherapy for Management of Macro/Mixed Cystic Lymphatic Malformation in Children.Frontiers in pediatrics · 2021Article
- Results of Injection Sclerotherapy with Bleomycin in Pediatric Lymphatic Malformations.Journal of Indian Association of Pediatric SurgeonsArticle
- Bleomycin Sclerotherapy in Massive Macrocystic Lymphatic Malformation: Minimal Complications with Maximum Results.Journal of cutaneous and aesthetic surgeryArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeSclerotherapy (ST) with bleomycin is an effective treatment for cervical cystic lymphatic malformations (LM) in children. However, its efficacy for treating extracervical cystic LM in children has not been investigated adequately. This retrospective study compares the efficacy of ST with surgery for treating extracervical cystic LM in children.
methodsThe subjects of this study were children treated for extracervical cystic LM at our hospital between 1970 and 2013. We evaluated retrospectively the hospital records of these children for age, gender, presenting symptoms, location of the lesion, radiological findings, treatments, complications, duration of hospitalization, and outcome.
resultsWe analyzed the records of 70 children (M:F = 1:9) with a mean age of 52.57 ± 54.87 months (range 1-204 months). The number of children treated by surgery alone, ST alone, and surgery plus ST was 53 (77 %), 13 (18 %), and 4 (5 %), respectively. Surgery comprised total excision (n = 41), near-total excision (n = 9), partial excision (n = 6), and incisional biopsy (n = 1). The complication and recurrence rates were lower, the complete response rate was higher, and the length of hospitalization was shorter in the ST group than in the surgery group (5 vs. 15 % and 8 vs. 17 %, respectively, p < 0.05; 91 vs. 77 %, respectively, p = 0.05; and 2.42 ± 1.67 vs. 13.57 ± 16.24 days, respectively, p = 0.03).
conclusionST is as safe as surgery for extracervical macrocystic or mixed LMs in children, but is much more effective with higher success rates and lower recurrence rates. Thus, ST provides a cost-effective and appropriate mode of treatment for children with extracervical cystic LM.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.