ArticleBiomaterials2015
Multi-functional self-fluorescent unimolecular micelles for tumor-targeted drug delivery and bioimaging.
Article in Biomaterials, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed.
- Article
- Synthesis of pH-Sensitive and Self-Fluorescent Polymeric Micelles Derived From Rosin and Vegetable OilsFrontiers in bioengineering and biotechnology · 2021Article
- A biodegradable nanocapsule delivers a Cas9 ribonucleoprotein complex for in vivo genome editing.Nature nanotechnology · 2019Article
- Cell penetrating peptides functionalized gambogic acid-nanostructured lipid carrier for cancer treatment.Drug delivery · 2018Article
- Complex Polymeric Architectures Self-Assembling in Unimolecular Micelles: Preparation, Characterization and Drug Nanoencapsulation.Pharmaceutics · 2018Review
- Strategies to improve micelle stability for drug delivery.Nano research · 2018Article
- A review on core-shell structured unimolecular nanoparticles for biomedical applications.Advanced drug delivery reviews · 2018Review
- CuS-Based Theranostic Micelles for NIR-Controlled Combination Chemotherapy and Photothermal Therapy and Photoacoustic Imaging.ACS applied materials & interfaces · 2017Article
- Tumor-targeted pH/redox dual-sensitive unimolecular nanoparticles for efficient siRNA delivery.Journal of controlled release : official journal of the Controlled Release Society · 2017Article
- Unimolecular Micelle-Based Hybrid System for Perivascular Drug Delivery Produces Long-Term Efficacy for Neointima Attenuation in Rats.Biomacromolecules · 2017Article
- Carboplatin-Complexed and cRGD-Conjugated Unimolecular Nanoparticles for Targeted Ovarian Cancer Therapy.Macromolecular bioscience · 2017Article
- Neuroendocrine Tumor-Targeted Upconversion Nanoparticle-Based Micelles for Simultaneous NIR-Controlled Combination Chemotherapy and Photodynamic Therapy, and Fluorescence Imaging.Advanced functional materials · 2017Article
- An intraocular drug delivery system using targeted nanocarriers attenuates retinal ganglion cell degeneration.Journal of controlled release : official journal of the Controlled Release Society · 2017Article
- AB3-Loaded and Tumor-Targeted Unimolecular Micelles for Medullary Thyroid Cancer Treatment.Journal of materials chemistry. B · 2017Article
- Aminoflavone-loaded EGFR-targeted unimolecular micelle nanoparticles exhibit anti-cancer effects in triple negative breast cancer.Biomaterials · 2016Article
- KE108-conjugated unimolecular micelles loaded with a novel HDAC inhibitor thailandepsin-A for targeted neuroendocrine cancer therapy.Biomaterials · 2016Article
- Periadventitial drug delivery for the prevention of intimal hyperplasia following open surgery.Journal of controlled release : official journal of the Controlled Release Society · 2016Review
- Thailandepsin A-loaded and octreotide-functionalized unimolecular micelles for targeted neuroendocrine cancer therapy.Biomaterials · 2016Article
- Dendritic Polymers for Theranostics.Theranostics · 2016Review
- Self-Reporting Degradable Fluorescent Grafted Copolymer Micelles Derived from Biorenewable Resources.ACS macro letters · 2015Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
A novel type of self-fluorescent unimolecular micelle nanoparticle (NP) formed by multi-arm star amphiphilic block copolymer, Boltron® H40 (H40, a 4th generation hyperbranched polymer)-biodegradable photo-luminescent polymer (BPLP)-poly(ethylene glycol) (PEG) conjugated with cRGD peptide (i.e., H40-BPLP-PEG-cRGD) was designed, synthesized, and characterized. The hydrophobic BPLP segment was self-fluorescent, thereby making the unimolecular micelle NP self-fluorescent. cRGD peptides, which can effectively target αvβ3 integrin-expressing tumor neovasculature and tumor cells, were selectively conjugated onto the surface of the micelles to offer active tumor-targeting ability. This unique self-fluorescent unimolecular micelle exhibited excellent photostability and low cytotoxicity, making it an attractive bioimaging probe for NP tracking for a variety of microscopy techniques including fluorescent microscopy, confocal laser scanning microscopy (CLSM), and two-photon microscopy. Moreover, this self-fluorescent unimolecular micelle NP also demonstrated excellent stability in aqueous solutions due to its covalent nature, high drug loading level, pH-controlled drug release, and passive and active tumor-targeting abilities, thereby making it a promising nanoplatform for targeted cancer theranostics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.