Evidence map›Paper›PMID 25682063›Full record

ArticleMetabolism: clinical and experimental2015

Triglycerides produced in the livers of fasting rabbits are predominantly stored as opposed to secreted into the plasma.

Demidmaa Tuvdendorj, Xiao-jun Zhang, David L Chinkes, Lijian Wang, Zhanpin Wu, Noe A Rodriguez, David N Herndon, Robert R Wolfe

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Metabolism: clinical and experimental, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Double-lobectomy in a steatotic liver transplantation rat model.Experimental and therapeutic medicine · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Demidmaa TuvdendorjDepartment of Metabolism Unit, Shriners Hospital for Children, University of Texas Medical Branch, Galveston, TX 77550, USA; Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX 77550, USA. Electronic address: detuvden@utmb.edu.
Xiao-jun ZhangDepartment of Metabolism Unit, Shriners Hospital for Children, University of Texas Medical Branch, Galveston, TX 77550, USA; Department of Surgery, University of Texas Medical Branch, Galveston, TX 77550, USA.
David L ChinkesDepartment of Metabolism Unit, Shriners Hospital for Children, University of Texas Medical Branch, Galveston, TX 77550, USA; Department of Surgery, University of Texas Medical Branch, Galveston, TX 77550, USA.
Lijian WangDepartment of Internal Medicine, University of Texas Medical Branch, Galveston, TX 77550, USA.
Zhanpin WuDepartment of Metabolism Unit, Shriners Hospital for Children, University of Texas Medical Branch, Galveston, TX 77550, USA; Department of Surgery, University of Texas Medical Branch, Galveston, TX 77550, USA.
Noe A RodriguezDepartment of Metabolism Unit, Shriners Hospital for Children, University of Texas Medical Branch, Galveston, TX 77550, USA; Department of Surgery, University of Texas Medical Branch, Galveston, TX 77550, USA.
David N HerndonDepartment of Metabolism Unit, Shriners Hospital for Children, University of Texas Medical Branch, Galveston, TX 77550, USA; Department of Surgery, University of Texas Medical Branch, Galveston, TX 77550, USA.
Robert R WolfeDepartment of Geriatrics, Center for Translational Research in Aging & Longevity, University of Arkansas Medical School, Little Rock, AR 72205, USA.
Shriners Hospitals for Children - Galveston · USThe University of Texas Medical Branch at Galveston · US

Funding

RESOURCE CORE 3: ANALYTICAL COREP30AG028718 · NIA · UNIV OF ARKANSAS FOR MED SCIS · PI WEI, JEANNE Y · 2011 to 2015
$5.1M
THE ROLE OF SUBSTRATE CYCLING IN ENERGY METABOLISMR01DK034817 · NIDDK · UNIV OF ARKANSAS FOR MED SCIS · PI WOLFE, ROBERT R · 1986 to 2013
$3.9M
NIA NIH HHS P30 AG028718NIA NIH HHS P30AG028718NIDDK NIH HHS R01 DK034817NIDDK NIH HHS R01, DK 034817
6 · The paper itself

Abstract

objectiveThe liver plays a central role in regulating fat metabolism; however, it is not clear how the liver distributes the synthesized triglycerides (TGs) to storage and to the plasma. MATERIALS AND

methodsWe have measured the relative distribution of TGs produced in the liver to storage and the plasma by means of U-(13)C(16)-palmitate infusion in anesthetized rabbits after an overnight fast.

resultsThe fractional synthesis rates of TGs stored in the liver and secreted into the plasma were not significantly different (stored vs. secreted: 31.9 ± 0.8 vs. 27.7 ± 2.6%∙h(-1), p > 0.05). However, the absolute synthesis rates of hepatic stored and secreted TGs were 543 ± 158 and 27 ± 7 nmol∙kg(-1)∙min(-1) respectively, indicating that in fasting rabbits the TGs produced in the liver were predominately stored (92 ± 3%) rather than secreted (8 ± 3%) into the plasma. This large difference was mainly due to the larger pool size of the hepatic TGs which was 21 ± 9-fold that of plasma TGs. Plasma free fatty acids (FFAs) contributed 47 ± 1% of the FA precursor for hepatic TG synthesis, and the remaining 53 ± 1% was derived from hepatic lipid breakdown and possibly plasma TGs depending on the activity of hepatic lipase. Plasma palmitate concentration significantly correlated with hepatic palmitoyl-CoA and TG synthesis.

conclusionIn rabbits, after an overnight fast, the absolute synthesis rate of hepatic stored TGs was significantly higher than that of secreted due to the larger pool size of hepatic TGs. The net synthesis rate of TG was approximately half the absolute rate. Plasma FFA is a major determinant of hepatic TG synthesis, and therefore hepatic TG storage.

Indexed as

AnimalsCarbon IsotopesFastingKineticsLiverMalePalmitatesPalmitoyl Coenzyme ARabbitsTriglyceridesCarbon IsotopesPalmitatesPalmitoyl Coenzyme ATriglyceridesMass spectrometryRabbit liverStable isotopesTriglyceride synthesisVery low density lipoprotein

Identifiers

PMID25682063
PMCPMC4372483
OpenAlexW2050960696

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.