Evidence map›Paper›PMID 25681871›Full record

ReviewBiological psychiatry2015

Multimodal approaches to define network oscillations in depression.

Otis Lkuwamy Smart, Vineet Ravi Tiruvadi, Helen S Mayberg

Abstract readReview
In one paragraph

Review in Biological psychiatry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 2 pooled it
7.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 2 syntheses or guidelines pooled it, 83 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Field potential 1/Journal of neurophysiology · 2019
    Trial
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  13. Invasive Computational Psychiatry.Biological psychiatry · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Otis Lkuwamy SmartDepartment of Neurosurgery, Emory University School of Medicine, Atlanta, Georgia.
Vineet Ravi TiruvadiDepartment of Biomedical Engineering, Georgia Institute of Technology, Emory University School of Medicine, Atlanta, Georgia.
Helen S MaybergDepartments of Psychiatry, Neurology, and Radiology, Emory University School of Medicine, Atlanta, Georgia.. Electronic address: hmayber@emory.edu.
Emory University · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM008169 · NIGMS · EMORY UNIVERSITY · PI GROSS, ROBERT E · 1987 to 2021
$20.3M
Special Scientific Procedures: Statistical Modeling CoreP50MH077083 · NIMH · EMORY UNIVERSITY · PI MAYBERG, HELEN S · 2006 to 2010
$9.3M
CRCNS: Patient-Specfic Models of Local Field Potentials in Subcallosal CingulateR01MH106173 · NIMH · CASE WESTERN RESERVE UNIVERSITY · PI MCINTYRE, CAMERON · 2014 to 2019
$2.0M
Autonomous Optogenetic Inhibition of Epileptic Activity Using a Bioluminescent LiR01NS079268 · NINDS · EMORY UNIVERSITY · PI GROSS, ROBERT E · 2012 to 2015
$1.4M
NIGMS NIH HHS T32 GM008169NIMH NIH HHS P50 MH077083NIMH NIH HHS R01 MH106173NINDS NIH HHS 3R01NS079268-02S1NINDS NIH HHS R01 NS079268
6 · The paper itself

Abstract

The renaissance in the use of encephalography-based research methods to probe the pathophysiology of neuropsychiatric disorders is well afoot and continues to advance. Building on the platform of neuroimaging evidence on brain circuit models, magnetoencephalography, scalp electroencephalography, and even invasive electroencephalography are now being used to characterize brain network dysfunctions that underlie major depressive disorder using brain oscillation measurements and associated treatment responses. Such multiple encephalography modalities provide avenues to study pathologic network dynamics with high temporal resolution and over long time courses, opportunities to complement neuroimaging methods and findings, and new approaches to identify quantitative biomarkers that indicate critical targets for brain therapy. Such goals have been facilitated by the ongoing testing of novel invasive neuromodulation therapies, notably, deep brain stimulation, where clinically relevant treatment effects can be monitored at multiple brain sites in a time-locked causal manner. We review key brain rhythms identified in major depressive disorder as foundation for development of putative biomarkers for objectively evaluating neuromodulation success and for guiding deep brain stimulation or other target-based neuromodulation strategies for treatment-resistant depression patients.

Indexed as

Models, NeurologicalAnimalsBiomarkersBrainBrain WavesDeep Brain StimulationElectroencephalographyHumansMajor Depressive DisorderNerve NetNeuroimagingBiomarkersDepressionElectrophysiologyNeurocircuitryNeuroimagingNeuromodulationTreatment-resistant

Identifiers

PMID25681871
PMCPMC5826645
OpenAlexW2025034488

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.