ArticleUrology2015
Endoscopic and histologic findings in a cohort of uric acid and calcium oxalate stone formers.
Article in Urology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 23 citations in OpenAlex.
- Neutrophil Secretory Proteins Inhibit Calcium Oxalate Crystallisation and Crystal Growth, but Promote Crystal Aggregation.Immunology · 2026Article
- Rare Earth Element and Yttrium Fingerprints in Human Kidney Stones: Tracing Environmental Exposure and Pathological Mineralization Pathway.Biological trace element research · 2026Article
- Effects of calcium oxalate crystals on neutrophil cellular proteome and functions: implications for nephrolithiasis.Cell communication and signaling : CCS · 2025Article
- Renal papillary tip biopsy in stone formers: a review of clinical safety and insights.Urolithiasis · 2024Review
- Differences of Uric Acid Transporters Carrying Extracellular Vesicles in the Urine from Uric Acid and Calcium Stone Formers and Non-Stone Formers.International journal of molecular sciences · 2022Article
- Patients treated for uric acid stones reoccur more often and within a shorter interval compared to patients treated for calcium stones.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2020Article
- Discrepancy Between Stone and Tissue Mineral Type in Patients with Idiopathic Uric Acid Stones.Journal of endourology · 2020Article
- Endoscopic observations as a tool to define underlying pathology in kidney stone formers.World journal of urology · 2019Article
- Activation of liver X receptor suppresses osteopontin expression and ameliorates nephrolithiasis.Journal of cellular physiology · 2019Article
- Mechanisms for falling urine pH with age in stone formers.American journal of physiology. Renal physiology · 2019Article
- Article
- Genome-Wide Gene Expression Profiling of Randall's Plaques in Calcium Oxalate Stone Formers.Journal of the American Society of Nephrology : JASN · 2017Article
- Kidney Function After the First Kidney Stone Event.Mayo Clinic proceedings · 2016Article
- Endoscopic description of renal papillary abnormalities in stone disease by flexible ureteroscopy: a proposed classification of severity and type.World journal of urology · 2016Article
- Integration and utilization of modern technologies in nephrolithiasis research.Nature reviews. Urology · 2016Review
- Idiopathic hypercalciuria and formation of calcium renal stones.Nature reviews. Nephrology · 2016Review
- Experimental models of renal calcium stones in rodents.World journal of nephrology · 2016Review
- Recent advances in understanding and managing urolithiasis.F1000Research · 2016Review
- Do kidney stone formers have a kidney disease?Kidney international · 2015Review
- Nephrolithiasis as a Risk Factor for CKD: The Atherosclerosis Risk in Communities Study.Clinical journal of the American Society of Nephrology : CJASN · 2015Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo characterize the endoscopic and histologic renal papillary lesions in a cohort of uric acid (UA) stone formers (SF).
methodsData were prospectively obtained during percutaneous nephrolithotomy between 2009 and 2013. Renal papillae were endoscopically analyzed to quantitate surface area occupied by plaque or plug, and biopsies were obtained. UA SF were compared with non-SF controls and patients with >50% calcium oxalate (CaOx) in the absence of UA.
resultsThere were 23 UA SF; of which 19 stones (83%) were admixed with CaOx and 4 (17%) were pure. Compared with CaOx SF and controls, UA SF had a higher prevalence of diabetes and obesity, greater serum creatinine and UA levels, lower estimated glomerular filtration rate and urine pH, and elevated UA supersaturation. Characteristics of UA SF were compared with 95 CaOx SF and 19 controls. Overall, 23 (100%) UA SF had endoscopic plaque and 13 (57%) plugs. Endoscopically, UA SF displayed a greater incidence of plugging (57% vs 45% vs 11%; P = .006) relative to CaOx SF and controls. Likewise, UA SF had a greater percentage surface area of plugging (0.1 vs 0.0; P = .002) and plaque (2.0 vs 0.9; P = .006) than controls but similar amounts to CaOx SF. Histologic plugs were similar in UA and CaOx SF, although CaOx SF demonstrated greater interstitial inflammation on endoscopic biopsy.
conclusionUA and CaOx SF have similar amounts of plaque, whereas UA SF have more endoscopic but not histologic collecting duct plugs. These data suggest an overlap between the pathogenesis of UA and CaOx stones. The anchoring site for UA stones remains uncertain.
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