Evidence map›Paper›PMID 25681709›Full record

ReviewCurrent opinion in virology2015

Viral diseases of the central nervous system.

Phillip A Swanson, Dorian B McGavern

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in virology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 178 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
178citing papers in PubMed, 3 pooled it
13.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

178 citing papers in PubMed, 3 syntheses or guidelines pooled it, 311 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Neurological Manifestations in COVID-19 Infection: A Systematic Review and Meta-Analysis.The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques · 2021
    Pooled it
  4. Article
  5. Article
  6. Review
  7. Article
  8. Immune signaling and function in neurodegeneration.The Journal of clinical investigation · 2026
    Review
  9. Review
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. Review

118 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Phillip A SwansonNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, United States.
Dorian B McGavernNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, United States. Electronic address: mcgavernd@mail.nih.gov.
National Institutes of Health · US

Funding

Pathogenesis of viral meningitisZIANS003112 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI MCGAVERN, DORIAN · 2009 to 2025
$33.6M
Mechanisms Underlying Clearance of the Persistently Infected CNSZIANS003111 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI MCGAVERN, DORIAN · 2009 to 2025
$33.0M
Intramural NIH HHS ZIA NS003111Intramural NIH HHS ZIA NS003112
6 · The paper itself

Abstract

Virus-induced diseases of the central nervous system (CNS) represent a significant burden to human health worldwide. The complexity of these diseases is influenced by the sheer number of different neurotropic viruses, the diverse routes of CNS entry, viral tropism, and the immune system. Using a combination of human pathological data and experimental animal models, we have begun to uncover many of the mechanisms that viruses use to enter the CNS and cause disease. This review highlights a selection of neurotropic viruses that infect the CNS and explores the means by which they induce neurological diseases such as meningitis, encephalitis, and myelitis.

Indexed as

AnimalsDisease Models, AnimalEncephalitis, ViralHost-Pathogen InteractionsHumansMeningitis, ViralMyelitisViruses

Identifiers

PMID25681709
PMCPMC4456224
OpenAlexW1999191464

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.