ArticleAnaerobe2015
Variation in germination of Clostridium difficile clinical isolates correlates to disease severity.
Article in Anaerobe, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed.
- Clostridioides difficile Sporulation.Advances in experimental medicine and biology · 2024Review
- Pathogenicity and virulence ofVirulence · 2023Review
- Bile salt hydrolases shape the bile acid landscape and restrict Clostridioides difficile growth in the murine gut.Nature microbiology · 2023Article
- Review
- Article
- Article
- Changes in the Association Between Diagnostic Testing Method, Polymerase Chain Reaction Ribotype, and Clinical Outcomes From Clostridioides difficile Infection: One Institution's Experience.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- Cultivation of Spore-Forming Gut Microbes Using a Combination of Bile Acids and Amino Acids.Microorganisms · 2021Article
- Treatment issues in recurrentFEMS microbes · 2020Review
- Ursodeoxycholic Acid (UDCA) Mitigates the Host Inflammatory Response during Clostridioides difficile Infection by Altering Gut Bile Acids.Infection and immunity · 2020Article
- Review
- Epidemic ribotypes of Clostridium (now Clostridioides) difficile are likely to be more virulent than non-epidemic ribotypes in animal models.BMC microbiology · 2020Article
- Article
- The CspC pseudoprotease regulates germination of Clostridioides difficile spores in response to multiple environmental signals.PLoS genetics · 2019Article
- Thinking Outside the Cereal Box: Noncarbohydrate Routes for Dietary Manipulation of the Gut Microbiota.Applied and environmental microbiology · 2019Review
- The requirement for co-germinants during Clostridium difficile spore germination is influenced by mutations in yabG and cspA.PLoS pathogens · 2019Article
- Article
- Updates to Clostridium difficile Spore Germination.Journal of bacteriology · 2018Review
- Article
- A Clostridium difficile-Specific, Gel-Forming Protein Required for Optimal Spore Germination.mBio · 2017Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Over the past two decades, Clostridium difficile infections have been increasing in both number and severity throughout the world. As with other spore forming bacteria, germination is a vital step in the life cycle of this pathogen. Studies have examined differences in sporulation and toxin production among a number of C. difficile clinical isolates; however, few have examined differences in germination and the relationship between this phenotype and disease severity. Here, over 100 C. difficile isolates from the University of Michigan Health System were examined for overall germination in response to various combinations of known germinants (taurocholate) and co-germinants (glycine and histidine). Significant variation was observed among isolates under all conditions tested. Isolates representing ribotype 014-020, which was the most frequently isolated ribotype at our hospital, exhibited increased germination in the presence of taurocholate and glycine when compared to isolates representing other ribotypes. Interestingly, isolates that caused severe disease exhibited significantly lower germination in response to minimal germination conditions (taurocholate only), indicating increased control over germination in these isolates. These data provide a broad picture of C. difficile isolate germination and indicate a role for precise control of germination in disease severity.
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Registered trials
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