ArticleJournal of virological methods2015
Virus characterization and discovery in formalin-fixed paraffin-embedded tissues.
Article in Journal of virological methods, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- Retrospective Analysis of Central Nervous System Diseases in Dogs, with Special Focus on Non-Suppurative Encephalomyelitis (1962-2022).Veterinary sciences · 2025Article
- Evaluating the potential of anti-dsRNA antibodies as an alternative viral sensing tool in encephalitides of different species.Frontiers in veterinary science · 2025Article
- Article
- Potential values of formalin-fixed paraffin-embedded tissues for intratumoral microbiome analysis in breast cancer.Heliyon · 2023Article
- Rustrela Virus as Putative Cause of Nonsuppurative Meningoencephalitis in Lions.Emerging infectious diseases · 2023Article
- Molecular Characterization of Avian Rotaviruses F and G Detected in Brazilian Poultry Flocks.Viruses · 2023Article
- InfectionCMA: A Cell MicroArray Approach for Efficient Biomarker Screening in In Vitro Infection Assays.Pathogens (Basel, Switzerland) · 2022Article
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- Ubiquitous influenza A virus in Chilean swine before the H1N1pdm09 introduction.Transboundary and emerging diseases · 2021Article
- Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Genome Sequencing from Post-Mortem Formalin-Fixed, Paraffin-Embedded Lung Tissues.The Journal of molecular diagnostics : JMD · 2021Article
- No Metagenomic Evidence of Causative Viral Pathogens in Postencephalitic Parkinsonism Following Encephalitis Lethargica.Microorganisms · 2021Article
- Detection and Phylogenetic Analyses of Taura Syndrome Virus from Archived Davidson's-Fixed Paraffin-Embedded Shrimp Tissue.Viruses · 2020Article
- Enhanced phylogenetic resolution of Newcastle disease outbreaks using complete viral genome sequences from formalin-fixed paraffin-embedded tissue samples.Virus genes · 2019Article
- Novel encephalomyelitis-associated astrovirus in a muskox (Ovibos moschatus): a surprise from the archives.Acta veterinaria Scandinavica · 2019Article
- Frequency of Epstein–Barr Virus DNA in Formalin-Fixed Paraffin-Embedded Tissue of Patients with Ductal Breast CarcinomaAsian Pacific journal of cancer prevention : APJCP · 2019Article
- Is Kawasaki disease an infectious disorder?International journal of rheumatic diseases · 2018Review
- Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Detection and characterization of novel viruses is hampered frequently by the lack of properly stored materials. Especially for the retrospective identification of viruses responsible for past disease outbreaks, often only formalin-fixed paraffin-embedded (FFPE) tissue samples are available. Although FFPE tissues can be used to detect known viral sequences, the application of FFPE tissues for detection of novel viruses is currently unclear. In the present study it was shown that sequence-independent amplification in combination with next-generation sequencing can be used to detect sequences of known and unknown viruses, although with relatively low sensitivity. These findings indicate that this technique could be useful for detecting novel viral sequences in FFPE tissues collected from humans and animals with disease of unknown origin, when other samples are not available. In addition, application of this method to FFPE tissues allows to correlate with the presence of histopathological changes in the corresponding tissue sections.
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Registered trials
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