Evidence map›Paper›PMID 25681502›Full record

ArticleMolecular cancer research : MCR2015

LncRNA Expression Discriminates Karyotype and Predicts Survival in B-Lymphoblastic Leukemia.

Thilini R Fernando, Norma I Rodriguez-Malave, Ella V Waters, Weihong Yan, David Casero, Giuseppe Basso, Martina Pigazzi, Dinesh S Rao

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular cancer research : MCR, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 107 citations in OpenAlex.

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  9. Transcriptome Analysis in Mexican Adults with Acute Lymphoblastic Leukemia.International journal of molecular sciences · 2024
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  20. Underexpression ofFrontiers in oncology · 2022
    Article

4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Thilini R FernandoDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, California.
Norma I Rodriguez-MalaveDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, California. Cellular and Molecular Pathology Ph.D. Program, University of California, Los Angeles, Los Angeles, California.
Ella V WatersDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, California.
Weihong YanDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, California.
David CaseroDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, California.
Giuseppe BassoWomen and Child Health Department-Hematology-Oncology Laboratory, University of Padova, Padova, Italy.
Martina PigazziWomen and Child Health Department-Hematology-Oncology Laboratory, University of Padova, Padova, Italy.
Dinesh S RaoDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, California. Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, California. Broad Stem Cell Research Center, University of California, Los Angeles, Los Angeles, California. drao@mednet.ucla.edu.
University of California, Los Angeles · USUniversity of Padua · IT

Funding

Women's CancersP30CA016042 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Samuel Wheeler French · 1985 to 2026
$134.5M
Virology CoreP30AI028697 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHEN, IRVIN S.Y. · 1991 to 2018
$39.9M
TUMOR CELL SURFACES AND CHROMOSOMEST32CA009056 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Gay M Crooks, David A. Nathanson · 1985 to 2026
$10.5M
Role of B-cell oncogenes and microRNA-34 in B-lymphopoiesis and neoplasiaK08CA133521 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RAO, DINESH S · 2009 to 2013
$784k
NCI NIH HHS K08 CA133521NCI NIH HHS K08CA133521NCI NIH HHS P30 CA016042NCI NIH HHS T32 CA009056NCI NIH HHS T32CA009056NIAID NIH HHS P30 AI028697
6 · The paper itself

Abstract

unlabelledLong noncoding RNAs (lncRNA) have been found to play a role in gene regulation with dysregulated expression in various cancers. The precise role that lncRNA expression plays in the pathogenesis of B-acute lymphoblastic leukemia (B-ALL) is unknown. Therefore, unbiased microarray profiling was performed on human B-ALL specimens, and it was determined that lncRNA expression correlates with cytogenetic abnormalities, which was confirmed by qRT-PCR in a large set of B-ALL cases. Importantly, high expression of BALR-2 correlated with poor overall survival and diminished response to prednisone treatment. In line with a function for this lncRNA in regulating cell survival, BALR-2 knockdown led to reduced proliferation, increased apoptosis, and increased sensitivity to prednisolone treatment. Conversely, overexpression of BALR-2 led to increased cell growth and resistance to prednisone treatment. Interestingly, BALR-2 expression was repressed by prednisolone treatment and its knockdown led to upregulation of the glucocorticoid response pathway in both human and mouse B cells. Together, these findings indicate that BALR-2 plays a functional role in the pathogenesis and/or clinical responsiveness of B-ALL, and that altering the levels of particular lncRNAs may provide a future direction for therapeutic development. IMPLICATIONS: lncRNA expression has the potential to segregate the common subtypes of B-ALL, predict the cytogenetic subtype, and indicate prognosis.

Indexed as

AnimalsApoptosisCell Growth ProcessesCohort StudiesGene Expression Regulation, LeukemicHumansKaryotypeMicePrecursor B-Cell Lymphoblastic Leukemia-LymphomaRNA, Long NoncodingSurvival AnalysisRNA, Long Noncoding

Identifiers

PMID25681502
PMCPMC4433429
OpenAlexW2126880994

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.