Evidence map›Paper›PMID 25681428›Full record

ReviewAmerican journal of physiology. Heart and circulatory physiology2015

Effects of exercise training on neurovascular control and skeletal myopathy in systolic heart failure.

Carlos E Negrao, Holly R Middlekauff, Igor L Gomes-Santos, Ligia M Antunes-Correa

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in American journal of physiology. Heart and circulatory physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 2 pooled it
15.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 48 citations in OpenAlex.

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  14. Coronary capillary blood flow in a rat model of congestive heart failure.Journal of applied physiology (Bethesda, Md. : 1985) · 2018
    Article
  15. Article
  16. Cardiac Cachexia: Perspectives for Prevention and Treatment.Arquivos brasileiros de cardiologia · 2017
    Review
  17. Article
  18. Article
  19. Exercise training in chronic heart failure: improving skeletal muscle O2 transport and utilization.American journal of physiology. Heart and circulatory physiology · 2015
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Carlos E NegraoHeart Institute (InCor), University of Sao Paulo Medical School, Sao Paulo, Brazil; School of Physical Education and Sport, University of Sao Paulo, Sao Paulo, Brazil; and cndnegrao@incor.usp.br.
Holly R MiddlekauffDepartament of Medicine (Cardiology) and Physiology, David Geffen School of Medicine at UCLA, University of California, Los Angeles, California.
Igor L Gomes-SantosHeart Institute (InCor), University of Sao Paulo Medical School, Sao Paulo, Brazil;
Ligia M Antunes-CorreaHeart Institute (InCor), University of Sao Paulo Medical School, Sao Paulo, Brazil;
Universidade de São Paulo · BRUniversity of California, Los Angeles · US

Funding

Sympathetic Nerve Activity and the Skeletal Myopathy of Heart FailureR01HL084525 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MIDDLEKAUFF, HOLLY R · 2007 to 2010
$1.5M
NHLBI NIH HHS R01 HL084525NHLBI NIH HHS R01-HL084525
6 · The paper itself

Abstract

Neurohormonal excitation and dyspnea are the hallmarks of heart failure (HF) and have long been associated with poor prognosis in HF patients. Sympathetic nerve activity (SNA) and ventilatory equivalent of carbon dioxide (VE/VO2) are elevated in moderate HF patients and increased even further in severe HF patients. The increase in SNA in HF patients is present regardless of age, sex, and etiology of systolic dysfunction. Neurohormonal activation is the major mediator of the peripheral vasoconstriction characteristic of HF patients. In addition, reduction in peripheral blood flow increases muscle inflammation, oxidative stress, and protein degradation, which is the essence of the skeletal myopathy and exercise intolerance in HF. Here we discuss the beneficial effects of exercise training on resting SNA in patients with systolic HF and its central and peripheral mechanisms of control. Furthermore, we discuss the exercise-mediated improvement in peripheral vasoconstriction in patients with HF. We will also focus on the effects of exercise training on ventilatory responses. Finally, we review the effects of exercise training on features of the skeletal myopathy in HF. In summary, exercise training plays an important role in HF, working synergistically with pharmacological therapies to ameliorate these abnormalities in clinical practice.

Indexed as

Exercise TherapyVasoconstrictionExercise ToleranceHeart Failure, SystolicHumansMuscle, SkeletalPulmonary Ventilationexercise trainingheart failureskeletal myopathysympathetic nerve activityvasoconstriction

Identifiers

PMID25681428
PMCPMC4398863
OpenAlexW2073023152

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.