ArticleBiology open2015
Transforming Growth Factor β/activin signalling induces epithelial cell flattening during Drosophila oogenesis.
Article in Biology open, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
- A computational framework to study EGFR signaling distribution in egg chambers during dynamic interactions between soma and germline.PLoS computational biology · 2025Article
- Ecdysone regulates phagocytic cell fate of epithelial cells in developing Drosophila eggs.The Journal of cell biology · 2025Article
- Finishing the egg.Genetics · 2024Article
- Two phases for centripetal migration of Drosophila melanogaster follicle cells: initial ingression followed by epithelial migration.Development (Cambridge, England) · 2023Article
- Developmental regulation of epithelial cell cuboidal-to-squamous transition in Drosophila follicle cells.Developmental biology · 2022Article
- A single-cell atlas reveals unanticipated cell type complexity inGenome research · 2021Article
- βPS-Integrin acts downstream of Innexin 2 in modulating stretched cell morphogenesis in the Drosophila ovary.G3 (Bethesda, Md.) · 2021Article
- Germline soma communication mediated by gap junction proteins regulates epithelial morphogenesis.PLoS genetics · 2021Article
- The ETS-transcription factor Pointed is sufficient to regulate the posterior fate of the follicular epithelium.Development (Cambridge, England) · 2020Article
- Gradient in cytoplasmic pressure in germline cells controls overlying epithelial cell morphogenesis.PLoS biology · 2020Article
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- Theory of Epithelial Cell Shape Transitions Induced by Mechanoactive Chemical Gradients.Biophysical journal · 2018Article
- A Cell Migration Tracking Tool Supports Coupling of Tissue Rotation to Elongation.Cell reports · 2017Article
- Mechanobiological induction of long-range contractility by diffusing biomolecules and size scaling in cell assemblies.Scientific reports · 2016Article
- Cellular and Nuclear Alignment Analysis for Determining Epithelial Cell Chirality.Annals of biomedical engineering · 2016Article
- Controlled expression of Drosophila homeobox loci using the Hostile takeover system.Developmental dynamics : an official publication of the American Association of Anatomists · 2015Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although the regulation of epithelial morphogenesis is essential for the formation of tissues and organs in multicellular organisms, little is known about how signalling pathways control cell shape changes in space and time. In the Drosophila ovarian epithelium, the transition from a cuboidal to a squamous shape is accompanied by a wave of cell flattening and by the ordered remodelling of E-cadherin-based adherens junctions. We show that activation of the TGFβ pathway is crucial to determine the timing, the degree and the dynamic of cell flattening. Within these cells, TGFβ signalling controls cell-autonomously the formation of Actin filament and the localisation of activated Myosin II, indicating that internal forces are generated and used to remodel AJ and to promote cytoskeleton rearrangement. Our results also reveal that TGFβ signalling controls Notch activity and that its functions are partly executed through Notch. Thus, we demonstrate that the cells that undergo the cuboidal-to-squamous transition produce active cell-shaping mechanisms, rather than passively flattening in response to a global force generated by the growth of the underlying cells. Thus, our work on TGFβ signalling provides new insights into the mechanisms through which signal transduction cascades orchestrate cell shape changes to generate proper organ structure.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.