Evidence map›Paper›PMID 25681375›Full record

ArticleThe Journal of infectious diseases2015

Oral Human Papillomavirus Infection and Oral Lesions in HIV-Positive and HIV-Negative Dental Patients.

Katia Muller, Julie Kazimiroff, Mahnaz Fatahzadeh, Richard V Smith, Mauricio Wiltz, Jacqueline Polanco, Robert M Grossberg, Thomas J Belbin, Howard D Strickler, Robert D Burk and 1 more

Registry-linked trialOpen access · bronzeAbstract read
In one paragraph

Article in The Journal of infectious diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00179361 (Natural History of Oral Cancer Precursors), which is not on this map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00179361 completednot on this map

Natural History of Oral Cancer Precursors

TypeobservationalSponsorAlbert Einstein College of MedicineRan2004 to 2014Enrolled374ConditionsPrecancerous Conditions, Leukoplakia, Erythroplasia, Oral Papillomas
3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 32 citations in OpenAlex.

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  13. Cannabis related side effects in otolaryngology: a scoping review.Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Katia MullerDepartment of Oral Health and Society, McGill Dentistry, Montreal, Canada.
Julie KazimiroffDepartment of Dentistry.
Mahnaz FatahzadehDepartment of Diagnostic Sciences, Rutgers School of Dental Medicine, Newark, New Jersey.
Richard V SmithDepartment of Otorhinolaryngology-Head and Neck Surgery Department of Pathology.
Mauricio WiltzDepartment of Dentistry.
Jacqueline PolancoDepartment of Dentistry.
Robert M GrossbergDivision of Infectious Diseases.
Thomas J BelbinDepartment of Pathology.
Howard D StricklerDepartment of Epidemiology and Population Health.
Robert D BurkDepartment of Epidemiology and Population Health Division of Genetics, Department of Pediatrics Department of Microbiology and Immunology Department of Obstetrics and Gynecology and Women's Health, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, New York.
Nicolas F SchlechtDivision of Oncology, Department of Medicine Department of Epidemiology and Population Health.
Albert Einstein College of Medicine · USMcGill University Health Centre · CAOffice of Infectious Diseases · USRutgers, The State University of New Jersey · US

Funding

WORD PROCESSORP30CA013330 · NCI · YESHIVA UNIVERSITY · PI THOMAS E ROHAN · 1985 to 2026
$111.2M
Immunology/Pathology CoreP30AI051519 · NIAID · YESHIVA UNIVERSITY · PI GOLDSTEIN, HARRIS · 2003 to 2013
$18.6M
Oral HPV and lesions in an HIV positive populationR21DE021671 · NIDCR · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI SCHLECHT, NICOLAS · 2011 to 2012
$467k
NCI NIH HHS P30 CA013330NIAID NIH HHS AI051519NIAID NIH HHS P30 AI051519NIDCR NIH HHS DE021671NIDCR NIH HHS R21 DE021671PHS HHS H97HA07517
6 · The paper itself

Abstract

We evaluated the risk factors associated with oral human papillomavirus (HPV) infection and oral lesions in 161 human immunodeficiency virus (HIV)-positive patients and 128 HIV-negative patients presenting for oral examination at 2 urban healthcare centers. Patients were interviewed on risk factors and provided oral-rinse samples for HPV DNA typing by polymerase chain reaction. Statistical associations were assessed by logistic regression. Oral HPV was prevalent in 32% and 16% of HIV-positive patients and HIV-negative patients, respectively, including high-risk HPV type 16 (8% and 2%, respectively; P = .049) and uncommon HPV types 32/42 (6% and 5%, respectively; P = .715). Among HIV-negative patients, significant risk factors for oral HPV included multiple sex partners (≥21 vs ≤5; odds ratio [OR], 9.1; 95% confidence interval [CI], 1.7-49.3), heavy tobacco smoking (>20 pack-years vs none; OR, 9.2; 95% CI, 1.4-59.4), and marijuana use (OR, 4.0; 95% CI, 1.3-12.4). Among HIV-positive patients, lower CD4(+) T-cell count only was associated with oral HPV detection (≤200 vs ≥500 cells/mm(3); OR, 4.5; 95% CI, 1.3-15.5). Detection of high-risk HPV was also associated with concurrent detection of potentially cancerous oral lesions among HIV-negative patients but not among HIV-positive patients. The observed risk factor associations with oral HPV in HIV-negative patients are consistent with sexual transmission and local immunity, whereas in HIV-positive patients, oral HPV detection is strongly associated with low CD4(+) T-cell counts.

Indexed as

AdultAgedAged, 80 and overDNA, ViralFemaleGenotypeHIV InfectionsHumansMaleMiddle AgedMouth DiseasesPapillomaviridaePapillomavirus InfectionsPolymerase Chain ReactionPrevalenceRisk FactorsDNA, ViralHIVhuman papillomavirus (HPV)immunityoral lesionssexual activity

Identifiers

PMID25681375
PMCPMC4539901
OpenAlexW2170987969

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.