Evidence map›Paper›PMID 25681310›Full record

ArticleNeuro-oncology2015

Posttranscriptional deregulation of signaling pathways in meningioma subtypes by differential expression of miRNAs.

Nicole Ludwig, Yoo-Jin Kim, Sabine C Mueller, Christina Backes, Tamara V Werner, Valentina Galata, Elke Sartorius, Rainer M Bohle, Andreas Keller, Eckart Meese

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuro-oncology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.

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  9. The Epigenetic Landscape of Meningiomas.Advances in experimental medicine and biology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Nicole LudwigDepartment of Human Genetics Medical School, Saarland University, Homburg/Saar, Germany (N.L., S.C.M., C.B., T.V.W., V.G., E.M.); Institute of Pathology Medical School, Saarland University, Homburg/Saar, Germany (Y.-J.K., E.S., R.M.B.); Chair for Clinical Bioinformatics, Saarland University, University Hospital, Saarbrücken, Germany (S.C.M., C.B., V.G., A.K.).
Yoo-Jin KimDepartment of Human Genetics Medical School, Saarland University, Homburg/Saar, Germany (N.L., S.C.M., C.B., T.V.W., V.G., E.M.); Institute of Pathology Medical School, Saarland University, Homburg/Saar, Germany (Y.-J.K., E.S., R.M.B.); Chair for Clinical Bioinformatics, Saarland University, University Hospital, Saarbrücken, Germany (S.C.M., C.B., V.G., A.K.).
Sabine C MuellerDepartment of Human Genetics Medical School, Saarland University, Homburg/Saar, Germany (N.L., S.C.M., C.B., T.V.W., V.G., E.M.); Institute of Pathology Medical School, Saarland University, Homburg/Saar, Germany (Y.-J.K., E.S., R.M.B.); Chair for Clinical Bioinformatics, Saarland University, University Hospital, Saarbrücken, Germany (S.C.M., C.B., V.G., A.K.).
Christina BackesDepartment of Human Genetics Medical School, Saarland University, Homburg/Saar, Germany (N.L., S.C.M., C.B., T.V.W., V.G., E.M.); Institute of Pathology Medical School, Saarland University, Homburg/Saar, Germany (Y.-J.K., E.S., R.M.B.); Chair for Clinical Bioinformatics, Saarland University, University Hospital, Saarbrücken, Germany (S.C.M., C.B., V.G., A.K.).
Tamara V WernerDepartment of Human Genetics Medical School, Saarland University, Homburg/Saar, Germany (N.L., S.C.M., C.B., T.V.W., V.G., E.M.); Institute of Pathology Medical School, Saarland University, Homburg/Saar, Germany (Y.-J.K., E.S., R.M.B.); Chair for Clinical Bioinformatics, Saarland University, University Hospital, Saarbrücken, Germany (S.C.M., C.B., V.G., A.K.).
Valentina GalataDepartment of Human Genetics Medical School, Saarland University, Homburg/Saar, Germany (N.L., S.C.M., C.B., T.V.W., V.G., E.M.); Institute of Pathology Medical School, Saarland University, Homburg/Saar, Germany (Y.-J.K., E.S., R.M.B.); Chair for Clinical Bioinformatics, Saarland University, University Hospital, Saarbrücken, Germany (S.C.M., C.B., V.G., A.K.).
Elke SartoriusDepartment of Human Genetics Medical School, Saarland University, Homburg/Saar, Germany (N.L., S.C.M., C.B., T.V.W., V.G., E.M.); Institute of Pathology Medical School, Saarland University, Homburg/Saar, Germany (Y.-J.K., E.S., R.M.B.); Chair for Clinical Bioinformatics, Saarland University, University Hospital, Saarbrücken, Germany (S.C.M., C.B., V.G., A.K.).
Rainer M BohleDepartment of Human Genetics Medical School, Saarland University, Homburg/Saar, Germany (N.L., S.C.M., C.B., T.V.W., V.G., E.M.); Institute of Pathology Medical School, Saarland University, Homburg/Saar, Germany (Y.-J.K., E.S., R.M.B.); Chair for Clinical Bioinformatics, Saarland University, University Hospital, Saarbrücken, Germany (S.C.M., C.B., V.G., A.K.).
Andreas KellerDepartment of Human Genetics Medical School, Saarland University, Homburg/Saar, Germany (N.L., S.C.M., C.B., T.V.W., V.G., E.M.); Institute of Pathology Medical School, Saarland University, Homburg/Saar, Germany (Y.-J.K., E.S., R.M.B.); Chair for Clinical Bioinformatics, Saarland University, University Hospital, Saarbrücken, Germany (S.C.M., C.B., V.G., A.K.).
Eckart MeeseDepartment of Human Genetics Medical School, Saarland University, Homburg/Saar, Germany (N.L., S.C.M., C.B., T.V.W., V.G., E.M.); Institute of Pathology Medical School, Saarland University, Homburg/Saar, Germany (Y.-J.K., E.S., R.M.B.); Chair for Clinical Bioinformatics, Saarland University, University Hospital, Saarbrücken, Germany (S.C.M., C.B., V.G., A.K.).
Saarland University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMicro (mi)RNAs are key regulators of gene expression and offer themselves as biomarkers for cancer development and progression. Meningioma is one of the most frequent primary intracranial tumors. As of yet, there are limited data on the role of miRNAs in meningioma of different histological subtypes and the affected signaling pathways.

methodsIn this study, we compared expression of 1205 miRNAs in different meningioma grades and histological subtypes using microarrays and independently validated deregulation of selected miRNAs with quantitative real-time PCR. Clinical utility of a subset of miRNAs as biomarkers for World Health Organization (WHO) grade II meningioma based on quantitative real-time data was tested. Potential targets of deregulated miRNAs were discovered with an in silico analysis.

resultsWe identified 13 miRNAs deregulated between different subtypes of benign meningiomas, and 52 miRNAs deregulated in anaplastic meningioma compared with benign meningiomas. Known and putative target genes of deregulated miRNAs include genes involved in epithelial-to-mesenchymal transition for benign meningiomas, and Wnt, transforming growth factor-β, and vascular endothelial growth factor signaling for higher-grade meningiomas. Furthermore, a 4-miRNA signature (miR-222, -34a*, -136, and -497) shows promise as a biomarker differentiating WHO grade II from grade I meningiomas with an area under the curve of 0.75.

conclusionsOur data provide novel insights into the contribution of miRNAs to the phenotypic spectrum in benign meningiomas. By deregulating translation of genes belonging to signaling pathways known to be important for meningioma genesis and progression, miRNAs provide a second in line amplification of growth promoting cellular signals. MiRNAs as biomarkers for diagnosis of aggressive meningiomas might prove useful and should be explored further in a prospective manner.

Indexed as

RNA Processing, Post-TranscriptionalSignal TransductionBiomarkers, TumorDisease ProgressionHumansMeningeal NeoplasmsMeningiomaMicroarray AnalysisMicroRNAsNeoplasm GradingBiomarkers, TumorMicroRNAshistological subtypesmeningiomamiRNAqRT-PCR

Identifiers

PMID25681310
PMCPMC4588755
OpenAlexW2012172158

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.