ReviewEukaryotic cell2015
How the necrotrophic fungus Alternaria brassicicola kills plant cells remains an enigma.
Review in Eukaryotic cell, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 86 citations in OpenAlex.
- The family of glutathione peroxidase proteins and their role against biotic stress in plants: a systematic review.Frontiers in plant science · 2025Pooled it
- Spray-Induced Gene Silencing (SIGS) of Dual-Target Genes (Journal of fungi (Basel, Switzerland) · 2026Article
- Identification of candidate regions associated with resistance to early blight in tomato (Solanum lycopersicum L.) using BSA-seq.Journal of applied genetics · 2026Article
- Comprehensive profiling of potato responses to Alternaria alternata and its toxins (TeA and AOH): ultrastructural, biochemical and multivariate insights.BMC plant biology · 2025Article
- Comprehensive study of tRNA-derived fragments in plants for biotic stress responses.Functional & integrative genomics · 2025Article
- Dual defense: melatonin simultaneously mitigates cadmium toxicity and southern blight in peanut.Frontiers in plant science · 2025Article
- A glycosylphosphatidylinositol-anchored protein from Alternaria alternata triggers cell death and negatively modulates immunity responses in chrysanthemum.Plant cell reports · 2024Article
- A method to determine antifungal activity in seed exudates by nephelometry.Plant methods · 2024Article
- Biocontrol Potential ofInternational journal of molecular sciences · 2023Article
- In vivo and In vitro evaluation of the antifungal activity of the PGPR Bacillus amyloliquefaciens RaSh1 (MZ945930) against Alternaria alternata with growth promotion influences on Capsicum annuum L. plants.Microbial cell factories · 2023Article
- Transcriptome sequencing leads to an improved understanding of the infection mechanism of Alternaria solani in potato.BMC plant biology · 2023Article
- Responses of Bunias orientalis to Short-term Fungal Infection and Insect Herbivory are Independent of Nutrient Supply.Journal of chemical ecology · 2022Article
- Seed Transmission of Pathogens: Non-Canonical Immune Response inPlants (Basel, Switzerland) · 2022Article
- Synthesis and antifungal activity of the proposed structure of a volatile compound isolated from the edible mushroomJournal of pesticide science · 2022Article
- Microbial interaction mediated programmed cell death in plants.3 Biotech · 2022Review
- The NecrotrophFrontiers in plant science · 2022Article
- The Effect of Photoperiod on Necrosis Development, Photosynthetic Efficiency and 'Green Islands' Formation inInternational journal of molecular sciences · 2021Article
- Transcription factor control of virulence in phytopathogenic fungi.Molecular plant pathology · 2021Review
- Prior exposure of Arabidopsis seedlings to mechanical stress heightens jasmonic acid-mediated defense against necrotrophic pathogens.BMC plant biology · 2020Article
- Complexity ofCells · 2020Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alternaria species are mainly saprophytic fungi, but some are plant pathogens. Seven pathotypes of Alternaria alternata use secondary metabolites of host-specific toxins as pathogenicity factors. These toxins kill host cells prior to colonization. Genes associated with toxin synthesis reside on conditionally dispensable chromosomes, supporting the notion that pathogenicity might have been acquired several times by A. alternata. Alternaria brassicicola, however, seems to employ a different mechanism. Evidence on the use of host-specific toxins as pathogenicity factors remains tenuous, even after a diligent search aided by full-genome sequencing and efficient reverse-genetics approaches. Similarly, no individual genes encoding lipases or cell wall-degrading enzymes have been identified as strong virulence factors, although these enzymes have been considered important for fungal pathogenesis. This review describes our current understanding of toxins, lipases, and cell wall-degrading enzymes and their roles in the pathogenesis of A. brassicicola compared to those of other pathogenic fungi. It also describes a set of genes that affect pathogenesis in A. brassicicola. They are involved in various cellular functions that are likely important in most organisms and probably indirectly associated with pathogenesis. Deletion or disruption of these genes results in weakly virulent strains that appear to be sensitive to the defense mechanisms of host plants. Finally, this review discusses the implications of a recent discovery of three important transcription factors associated with pathogenesis and the putative downstream genes that they regulate.
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