ArticleMolecular & cellular proteomics : MCP2015
Integrated transcriptomic and proteomic analysis of the global response of Synechococcus to high light stress.
Article in Molecular & cellular proteomics : MCP, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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27 citing papers in PubMed, 61 citations in OpenAlex.
- Bacterial stress responses lower mRNA-protein level correlations.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Cyanobacteria as a Photosynthetic Chassis for Metabolic Pathway Engineering with Heterologous Gene Expression.Current issues in molecular biology · 2026Review
- Improving tolerance to fluctuating light through adaptive laboratory evolution in the cyanobacterium Synechocystis.Nature communications · 2026Article
- Integrated analysis of transcriptome and proteome under salinity stress from leaf tissues of Pisum sativum.Plant molecular biology · 2026Article
- Duckweed (Aquaculture nutrition · 2026Article
- Duckweed as a Sustainable Aquafeed: Effects on Growth, Muscle Composition, Antioxidant and Immune Markers in Grass Carp.Animals : an open access journal from MDPI · 2025Article
- Molecular glue for phycobilisome attachment to photosystem II inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Biocompatibility ofInternational journal of molecular sciences · 2024Article
- Dynamic Changes in the Thylakoid Proteome of Cyanobacteria during Light-Regulated Thylakoid Membrane Development.Plants (Basel, Switzerland) · 2023Article
- Plastoquinone Lipids: Their Synthesis via a Bifunctional Gene and Physiological Function in a Euryhaline Cyanobacterium,Microorganisms · 2023Article
- Highlighting the potential ofFrontiers in microbiology · 2023Article
- Integration of transcriptomic and proteomic analyses reveals several levels of metabolic regulation in the excess starch and early senescent leaf mutant lses1 in rice.BMC plant biology · 2022Article
- CyanoOmicsDB: an integrated omics database for functional genomic analysis of cyanobacteria.Nucleic acids research · 2022Article
- Transcriptomic and Phenomic Investigations Reveal Elements in Biofilm Repression and Formation in the CyanobacteriumFrontiers in microbiology · 2022Article
- Comparative transcriptomic and lipidomic analyses indicate that cold stress enhanced the production of the long C18-C22 polyunsaturated fatty acids inFrontiers in microbiology · 2022Article
- Slr0320 Is Crucial for Optimal Function of Photosystem II during High Light Acclimation inLife (Basel, Switzerland) · 2021Article
- The Two TpsB-Like Proteins inJournal of bacteriology · 2021Article
- A Hybrid Flux Balance Analysis and Machine Learning Pipeline Elucidates Metabolic Adaptation in Cyanobacteria.iScience · 2020Article
- Blue light induces major changes in the gene expression profile of the cyanobacterium Synechocystis sp. PCC 6803.Physiologia plantarum · 2020Article
- Low-temperature effects on docosahexaenoic acid biosynthesis inBiotechnology for biofuels · 2020Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sufficient light is essential for the growth and physiological functions of photosynthetic organisms, but prolonged exposure to high light (HL) stress can cause cellular damage and ultimately result in the death of these organisms. Synechococcus sp. PCC 7002 (hereafter Synechococcus 7002) is a unicellular cyanobacterium with exceptional tolerance to HL intensities. However, the molecular mechanisms involved in HL response by Synechococcus 7002 are not well understood. Here, an integrated RNA sequencing transcriptomic and quantitative proteomic analysis was performed to investigate the cellular response to HL in Synechococcus 7002. A total of 526 transcripts and 233 proteins were identified to be differentially regulated under HL stress. Data analysis revealed major changes in mRNAs and proteins involved in the photosynthesis pathways, resistance to light-induced damage, DNA replication and repair, and energy metabolism. A set of differentially expressed mRNAs and proteins were validated by quantitative RT-PCR and Western blot, respectively. Twelve genes differentially regulated under HL stress were selected for knockout generation and growth analysis of these mutants led to the identification of key genes involved in the response of HL in Synechococcus 7002. Taken altogether, this study established a model for global response mechanisms to HL in Synechococcus 7002 and may be valuable for further studies addressing HL resistance in photosynthetic organisms.
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