ReviewJournal of molecular biology2015
A first line of stress defense: small heat shock proteins and their function in protein homeostasis.
Review in Journal of molecular biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 303 papers.
What it found
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Who cites it
303 citing papers in PubMed.
- A Heat-Inducible Rubisco Activase Safeguards Photosynthesis via Multilevel Regulation and Dual Function.Plant biotechnology journal · 2026Article
- The kinetic basis of photosynthetic heat tolerance.Nature ecology & evolution · 2026Article
- Alternative splicing acts as a strategic switch for heat shock network diversification under escalating heat stress.Plant cell reports · 2026Article
- Genome-Wide Characterization and Heat Responsive Expression Profiling of the HSP10 Co-Chaperonin Gene Family inInternational journal of molecular sciences · 2026Article
- Identification and characterization of a gene conferring stress resistance in Escherichia coli and cyanobacteria.FEBS open bio · 2026Article
- Oxidative stress impacts carbon metabolism and induces upregulation of redox enzymes andsmall secreted proteins in the wood-decay fungus.Fungal biology and biotechnology · 2026Article
- Desiccation tolerance mechanisms in the green lineage and beyond.The New phytologist · 2026Review
- Review
- Suborbital spaceflight reveals rapid changes in gene expression accompanying the transition to and from space.NPJ microgravity · 2026Article
- Toxicoproteomic analysis reveals arsenic-induced alterations in eye lens proteins of Labeo rohita.Fish physiology and biochemistry · 2026Article
- Molecular mechanisms and energetic costs of recovery from freezing in the polyextremophile midge Belgica antarctica.The Journal of experimental biology · 2026Article
- Role of Antioxidant Systems and Heat Shock Response in Aquatic Animals Under Multistress Conditions.Antioxidants (Basel, Switzerland) · 2026Review
- CIA5 and its interacting metal-binding GTPase ZNG3 are degraded by the proteasome in Zn deficiency.The Plant journal : for cell and molecular biology · 2026Article
- Structural-Molecular Linkage Shapes the Adaptive Traits of Nuptial Pads in Male Rana chensinensis.Cell biochemistry and function · 2026Article
- Molecular Equilibrist: The Small Heat Shock Protein IbpA from Mycoplasma.Biomolecules · 2026Article
- Transcriptional insights into molecular events occurring during tuber maturation of tigernut (Cyperus esculentus L.).Functional & integrative genomics · 2026Article
- Human Crystallin Variation and Cataract.Investigative ophthalmology & visual science · 2026Review
- Low-temperature stress modulates pollen tube growth through temperature-dependent multi-level regulatory mechanisms in Camellia sinensis.Plant reproduction · 2026Article
- Small heat shock proteins and biomolecular condensates.Cellular and molecular life sciences : CMLS · 2026Review
- Structural and functional characterization of sHsp from the marine cyanobacteriumBiochemistry and biophysics reports · 2026Article
243 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Small heat shock proteins (sHsps) are virtually ubiquitous molecular chaperones that can prevent the irreversible aggregation of denaturing proteins. sHsps complex with a variety of non-native proteins in an ATP-independent manner and, in the context of the stress response, form a first line of defense against protein aggregation in order to maintain protein homeostasis. In vertebrates, they act to maintain the clarity of the eye lens, and in humans, sHsp mutations are linked to myopathies and neuropathies. Although found in all domains of life, sHsps are quite diverse and have evolved independently in metazoans, plants and fungi. sHsp monomers range in size from approximately 12 to 42kDa and are defined by a conserved β-sandwich α-crystallin domain, flanked by variable N- and C-terminal sequences. Most sHsps form large oligomeric ensembles with a broad distribution of different, sphere- or barrel-like oligomers, with the size and structure of the oligomers dictated by features of the N- and C-termini. The activity of sHsps is regulated by mechanisms that change the equilibrium distribution in tertiary features and/or quaternary structure of the sHsp ensembles. Cooperation and/or co-assembly between different sHsps in the same cellular compartment add an underexplored level of complexity to sHsp structure and function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.