ArticleSocial cognitive and affective neuroscience2015
Interaction between oxytocin receptor polymorphism and interdependent culture values on human empathy.
Article in Social cognitive and affective neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Does losing money truly hurt? The shared neural bases of monetary loss and pain.Human brain mapping · 2022Pooled it
- Intranasal oxytocin decreases self-oriented learning.Psychopharmacology · 2021Trial
- Empathy levels among health sciences professors in Latin America: distribution, classification and gender differences.BMC medical education · 2025Article
- Adolescents Are More Utilitarian Than Adults in Group Moral Decision-Making.PsyCh journal · 2025Article
- The influence of class mobility on pain empathy among the wealthy in collectivist cultures: evidence from ERPs.Frontiers in human neuroscience · 2025Article
- Patterns of neural activity in response to threatening faces are predictive of autistic traits: modulatory effects of oxytocin receptor genotype.Translational psychiatry · 2024Article
- Neural representation of perceived race mediates the opposite relationship between subcomponents of self-construals and racial outgroup punishment.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Situational factors shape moral judgements in the trolley dilemma in Eastern, Southern and Western countries in a culturally diverse sample.Nature human behaviour · 2022Article
- Cognitive and neural bases of decision-making causing civilian casualties during intergroup conflict.Nature human behaviour · 2021Article
- Empathy and Hormonal Changes as Predictors of Sensitive Responsiveness towards Infant Crying: A Study Protocol.International journal of environmental research and public health · 2021Article
- Recalled Parental Bonding Interacts with Oxytocin Receptor Gene Polymorphism in Modulating Anxiety and Avoidance in Adult Relationships.Brain sciences · 2021Article
- Impact ofFrontiers in genetics · 2021Article
- Symphony of Well-Being: Harmony Between Neural Variability and Self-Construal.Frontiers in human neuroscience · 2021Article
- Social Cognition in a Research Domain Criteria Perspective: A Bridge Between Schizophrenia and Autism Spectra Disorders.Frontiers in psychiatry · 2020Review
- Interactions between oxytocin receptor gene and intergroup relationship on empathic neural responses to others' pain.Social cognitive and affective neuroscience · 2019Article
- Structural neuroimaging correlates of social deficits are similar in autism spectrum disorder and attention-deficit/hyperactivity disorder: analysis from the POND Network.Translational psychiatry · 2019Article
- Developmental aspects in cultural neuroscience.Developmental review : DR · 2018Article
- Functional connectivity pattern underlies individual differences in independent self-construal.Social cognitive and affective neuroscience · 2018Article
- Oxytocin Enhancement of Emotional Empathy: Generalization Across Cultures and Effects on Amygdala Activity.Frontiers in neuroscience · 2018Article
- Embodiment and Humiliation Moderation of Neural Responses to Others' Suffering in Female Submissive BDSM Practitioners.Frontiers in neuroscience · 2018Article
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent evidence suggests that the association between oxytocin receptor polymorphism (OXTR rs53576) and emotion-related behavioral/psychological tendencies differs between individuals from East Asian and Western cultures. What remains unresolved is which specific dimension of cultural orientations interacts with OXTR rs53576 to shape these tendencies and whether such gene × culture interactions occurs at both behavioral and neural level. This study investigated whether and how OXTR rs53576 interacts with interdependence-a key dimension of cultural orientations that distinguish between East Asian and Western cultures-to affect human empathy that underlies altruistic motivation and prosocial behavior. Experiment 1 measured interdependence, empathy trait and OXTR rs53576 genotypes of 1536 Chinese participants. Hierarchical regression analyses revealed a stronger association between interdependence and empathy trait in G allele carriers compared with A/A homozygotes of OXTR rs53576. Experiment 2 measured neural responses to others' suffering by scanning A/A and G/G homozygous of OXTR rs53576 using functional magnetic resonance imaging. Hierarchical regression analyses revealed stronger associations between interdependence and empathic neural responses in the insula, amygdala and superior temporal gyrus in G/G compared with A/A carriers. Our results provide the first evidence for gene × culture interactions on empathy at both behavioral tendency and underlying brain activity.
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