ArticleSocial cognitive and affective neuroscience2015
Reducing proactive aggression through non-invasive brain stimulation.
Article in Social cognitive and affective neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 3 of them syntheses that pooled it.
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The trial behind it
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Who cites it
48 citing papers in PubMed, 3 syntheses or guidelines pooled it, 135 citations in OpenAlex.
- A Meta-Analysis of the Effects of Transcranial Direct Current Stimulation on Anger and Aggression.Aggressive behavior · 2025Pooled it
- Noninvasive brain stimulation in children and adults with attention-deficit/hyperactivity disorder: a systematic review and meta-analysis.Journal of psychiatry & neuroscience : JPN · 2021Pooled it
- An overlapping pattern of cerebral cortical thinning is associated with both positive symptoms and aggression in schizophrenia via the ENIGMA consortium.Psychological medicine · 2020Pooled it
- Targeting aggression with prefrontal high-definition transcranial direct current stimulation.Scientific reports · 2026Trial
- Stimulation of the Prefrontal Cortex Reduces Intentions to Commit Aggression: A Randomized, Double-Blind, Placebo-Controlled, Stratified, Parallel-Group Trial.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Trial
- Neuromodulation can reduce aggressive behavior elicited by violent video games.Cognitive, affective & behavioral neuroscience · 2017Trial
- Approach Motivation and Reward Sensitivity: Effects of High-Definition Transcranial Direct Current Stimulation (HD-tDCS) to Brain Hemispheres on Effort-Related Cardiovascular Response.The European journal of neuroscience · 2026Article
- Measuring proactive-instrumental aggression in adolescents and young adults-development and preliminary validity evidence for the Degree-of-Quiz-Difficulty Paradigm.Frontiers in psychology · 2026Article
- Review: Suicide and its relationship to aggression and impulsivity.Cognitive, affective & behavioral neuroscience · 2025Review
- Modulating interhemispheric prefrontal dynamics of aggressive behavior: Sex differences and the association with personal disposition.Cognitive, affective & behavioral neuroscience · 2025Article
- Narcissistic and Antisocial Personality Traits Are Both Encoded in the Triple Network: Connectomics Evidence.Psychophysiology · 2025Article
- Mapping Lesion-Related Human Aggression to a Common Brain Network.Biological psychiatry · 2025Article
- Is Being Male a Marker of Aggression? Evidence for the Decoupling of Sex and Gender Role Orientation.Brain sciences · 2024Article
- Hostile Attribution Bias Shapes Neural Synchrony in the Left Ventromedial Prefrontal Cortex during Ambiguous Social Narratives.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Brain Anatomy in Boys with Conduct Disorder: Differences Among Aggression Subtypes.Child psychiatry and human development · 2024Article
- Associations among Parental Phubbing, Self-esteem, and Adolescents' Proactive and Reactive Aggression: A Three-Year Longitudinal Study in China.Journal of youth and adolescence · 2024Article
- Neuroanatomical correlates of aggressiveness: a case-control voxel- and surface-based morphometric study.Brain structure & function · 2024Article
- A fronto-insular network underlies individual variations in anger expression and control.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- The Effect of Multi-Session Prefrontal Cortical Stimulation on Aggression: A Randomized, Double-Blind, Parallel-Group Trial.Life (Basel, Switzerland) · 2023Article
- Non-Invasive Brain Stimulation for the Modulation of Aggressive Behavior-A Systematic Review of Randomized Sham-Controlled Studies.Life (Basel, Switzerland) · 2023Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aggressive behavior poses a threat to human collaboration and social safety. It is of utmost importance to identify the functional mechanisms underlying aggression and to develop potential interventions capable of reducing dysfunctional aggressive behavior already at a brain level. We here experimentally shifted fronto-cortical asymmetry to manipulate the underlying motivational emotional states in both male and female participants while assessing the behavioral effects on proactive and reactive aggression. Thirty-two healthy volunteers received either anodal transcranial direct current stimulation to increase neural activity within right dorsolateral prefrontal cortex, or sham stimulation. Aggressive behavior was measured with the Taylor Aggression Paradigm. We revealed a general gender effect, showing that men displayed more behavioral aggression than women. After the induction of right fronto-hemispheric dominance, proactive aggression was reduced in men. This study demonstrates that non-invasive brain stimulation can reduce aggression in men. This is a relevant and promising step to better understand how cortical brain states connect to impulsive actions and to examine the causal role of the prefrontal cortex in aggression. Ultimately, such findings could help to examine whether the brain can be a direct target for potential supportive interventions in clinical settings dealing with overly aggressive patients and/or violent offenders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.