ArticleEcotoxicology (London, England)2015
Metallothionein from Pseudosciaena crocea: expression and response to cadmium-induced injury in the testes.
Article in Ecotoxicology (London, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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Who cites it
6 citing papers in PubMed, 14 citations in OpenAlex.
- Melatonin Supplementation Relieves Fluoride-Induced Bone Injury via Ion Homeostasis Disorder and PINK1/Parkin-Mediated Mitophagy.Foods (Basel, Switzerland) · 2025Article
- Expression and Functional Analysis of the Metallothionein and Metal-Responsive Transcription Factor 1 inInternational journal of molecular sciences · 2024Article
- Emerging insights into the impacts of heavy metals exposure on health, reproductive and productive performance of livestock.Frontiers in pharmacology · 2024Review
- Cadmium Through Disturbing MTF1-Mediated Metal Response Induced Cerebellar Injury.Neurotoxicity research · 2022Article
- Cloning, Functional Characterization and Response to Cadmium Stress of the Thioredoxin-like Protein 1 Gene fromInternational journal of molecular sciences · 2021Article
- Effects of cadmium exposure on medaka (Journal of toxicologic pathology · 2017Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metallothioneins (MTs) are a family of stress proteins that are involved in the process of detoxification and anti-oxidation. Previous studies have focused mostly on the expression and functions of MTs in the non-reproductive tissues of aquatic vertebrates. However, there have been only a few reports regarding the functions of MTs in the reproductive tissues of such vertebrates. In order to investigate the function of MTs during spermatogenesis in Pseudosciaena crocea, reverse-transcription polymerase chain reaction (PCR) and rapid amplification of cDNA ends were performed to obtain the P. crocea MT complete cDNA sequence from the total RNA of the testes for the first time. MT was detected in the liver, kidneys, testes, spleen, gill and muscle of P. crocea by tissue-specific expression analysis. Meanwhile, immunohistochemistry staining indicated that the MT protein was localized in germ cells, Sertoli cells and the peripheral connective tissues in P. crocea testes. Furthermore, acute toxicity tests were conducted with cadmium (Cd) to determine the 96 h-medial lethal concentration value. The toxic effects of Cd on the microstructure and ultrastructure of the testes were observed. In addition, the changes in MT mRNA expression levels in the testes after Cd exposure were measured using real-time quantitative PCR. Consequently, we suggest that MTs play an important role in spermatogenesis and testes protection against Cd toxicity in P. crocea.
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