ArticleGenetics2015
Novel tools for genetic manipulation of follicle stem cells in the Drosophila ovary reveal an integrin-dependent transition from quiescence to proliferation.
Article in Genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 29 citations in OpenAlex.
- Starve-Feed Cycles Direct Quiescence to Proliferation Transitions inbioRxiv : the preprint server for biology · 2026Article
- Thousands of students gain science research literacy and agency by conducting immersive Drosophila research projects tailored to the health interests of their communities.Developmental biology · 2025Article
- Non-apoptotic caspase activation ensures the homeostasis of ovarian somatic stem cells.EMBO reports · 2023Article
- Sequential events during the quiescence to proliferation transition establish patterns of follicle cell differentiation in the Drosophila ovary.Biology open · 2023Article
- MiMIC analysis reveals an isoform specific role for Drosophila Musashi in follicle stem cell maintenance and escort cell function.Cell death discovery · 2022Article
- brinker levels regulated by a promoter proximal element support germ cell homeostasis.Development (Cambridge, England) · 2022Article
- Investigating Adult Stem Cells Through Lineage analyses.Stem cell reviews and reports · 2022Review
- A single-cell atlas reveals unanticipated cell type complexity inGenome research · 2021Article
- Protocol for evaluating autophagy using LysoTracker staining in the epithelial follicle stem cells of theSTAR protocols · 2021Article
- Nuclear receptors linking physiology and germline stem cells in Drosophila.Vitamins and hormones · 2021Review
- Article
- The role of integrins inDevelopment (Cambridge, England) · 2019Article
- Loss of putzig in the germline impedes germ cell development by inducing cell death and new niche like microenvironments.Scientific reports · 2019Article
- Opposing Action of Hedgehog and Insulin Signaling Balances Proliferation and Autophagy to Determine Follicle Stem Cell Lifespan.Developmental cell · 2018Article
- Article
- Stonewall and Brickwall: Two Partially Redundant Determinants Required for the Maintenance of Female Germline inG3 (Bethesda, Md.) · 2018Article
- Alternative direct stem cell derivatives defined by stem cell location and graded Wnt signalling.Nature cell biology · 2017Article
- Article
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 1 country.
Funding
Abstract
In many tissues, the presence of stem cells is inferred by the capacity of the tissue to maintain homeostasis and undergo repair after injury. Isolation of self-renewing cells with the ability to generate the full array of cells within a given tissue strongly supports this idea, but the identification and genetic manipulation of individual stem cells within their niche remain a challenge. Here we present novel methods for marking and genetically altering epithelial follicle stem cells (FSCs) within the Drosophila ovary. Using these new tools, we define a sequential multistep process that comprises transitioning of FSCs from quiescence to proliferation. We further demonstrate that integrins are cell-autonomously required within FSCs to provide directional signals that are necessary at each step of this process. These methods may be used to define precise roles for specific genes in the sequential events that occur during FSC division after a period of quiescence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.