Evidence map›Paper›PMID 25680740›Full record

ArticleLupus2015

Predictors of kidney disease in a cohort of pediatric patients with lupus.

S D Sule, D G Moodalbail, J Burnham, B Fivush, S L Furth

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Lupus, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 32 citations in OpenAlex.

  1. New Insights on Childhood Lupus Nephritis.International journal of nephrology and renovascular disease · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

S D SuleJohns Hopkins University, Baltimore, MD, USA ssule@jhmi.edu.
D G MoodalbailNemours/Alfred I. duPont Hospital for Children, Wilmington, DE, USA.
J BurnhamDepartment of Pediatrics, Perelman School of Medicine at the University of Pennsylvania and the Children's Hospital of Philadelphia, USA.
B FivushJohns Hopkins University, Baltimore, MD, USA.
S L FurthDepartment of Pediatrics, Perelman School of Medicine at the University of Pennsylvania and the Children's Hospital of Philadelphia, USA Department of Epidemiology and Biostatistics, Perelman School of Medicine at the University of Pennsylvania, USA.
Johns Hopkins University · USAlfred I. duPont Hospital for Children · USChildren's Hospital of Philadelphia · USUniversity of Pennsylvania · US

Funding

Patient Oriented Research in Pediatric Kidney DiseaseK24DK078737 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI FURTH, SUSAN L. · 2007 to 2016
$1.6M
Cohort Study of Pediatric SLEK23AR052736 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI SULE, SANGEETA DILEEP · 2008 to 2012
$678k
NIAMS NIH HHS 5K23AR052736NIAMS NIH HHS K23 AR052736NIDDK NIH HHS K24 DK078737
6 · The paper itself

Abstract

introductionChildren with systemic lupus erythematosus (SLE) have an increased prevalence of kidney disease compared to their adult counterparts. Our goal was to identify potential clinical and laboratory predictors of renal disease.

methodsWe performed a cohort study of incident and prevalent patients with SLE aged ≤19 years. Retrospective data from initial presentation until study enrollment was also collected. Laboratory and clinic data were recorded from each clinic visit including disease activity indices, autoantibodies, urinalyses, blood counts, and metabolic profile. Kidney disease was defined as the presence of abnormal renal biopsy or by American College of Rheumatology case definition for lupus nephritis. Logistic regression analyses were used to determine the association between clinical and laboratory data with kidney disease in those who had renal involvement within 30 days of SLE diagnosis. We also performed a time to event analysis to identify antecedents of renal disease.

resultsForty-seven children and adolescents with SLE were followed in the cohort, 91% female and 68% black. All of the males in the cohort developed renal disease, and all within one month of the diagnosis of SLE. In logistic regression, low serum albumin (odds ratio (OR): 4.8, 95% CI: 1.9-12.5) and positive dsDNA antibodies (OR: 3.2, 95% CI: 1.7-5.9) were associated with kidney disease. In longitudinal analyses, isolated sterile pyuria (hazard ratio (HR): 3, 95% CI: 1.1-6.4) and low serum albumin (HR: 3.4, 95% CI: 1.7-6.9) were predictors of future kidney disease. The presence of antibodies against Ro were protective against renal disease (HR: 0.2, 95% CI: 0.05-0.5).

conclusionWe identified variables associated with kidney disease, both at initial diagnosis of SLE and in longitudinal follow-up in a cohort of children with SLE. The recognition of these abnormal laboratory values may help clinicians identify patients at risk for kidney disease before its onset thus preventing long-term complications.

Indexed as

AdolescentAutoantibodiesBlack or African AmericanChildFemaleHumansKidneyLogistic ModelsLupus NephritisMaleOdds RatioPrognosisRetrospective StudiesRisk FactorsAutoantibodiesnephritisRenal lupussystemic lupus erythematosus

Identifiers

PMID25680740
PMCPMC4466076
OpenAlexW2056345576

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.