ArticleDiabetologia2015
Serum albumin concentration and incident type 2 diabetes risk: new findings from a population-based cohort study.
Article in Diabetologia, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 4 of them syntheses that pooled it.
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Who cites it
38 citing papers in PubMed, 4 syntheses or guidelines pooled it, 79 citations in OpenAlex.
- The interplay between circulating high-density lipoprotein, age and fracture risk: a new cohort study and systematic meta-analysis.GeroScience · 2023Pooled it
- Pooled it
- Renin-angiotensin system inhibitors and risk of fractures: a prospective cohort study and meta-analysis of published observational cohort studies.European journal of epidemiology · 2017Pooled it
- Serum C-reactive protein increases the risk of venous thromboembolism: a prospective study and meta-analysis of published prospective evidence.European journal of epidemiology · 2017Pooled it
- Development of a risk assessment model for multimorbidity of diabetes, hypertension, and coronary heart disease with XGBoost in primary care in Shanghai, China: a retrospective study.BMC cardiovascular disorders · 2026Article
- Serum Albumin as a Prognostic Marker in Geriatric Intermediate Care: A Retrospective Cohort Study.Cureus · 2025Article
- Hepatic Satellite Cell Activation and Alteration of Vitamin A Status Are Relevant to the Aggravation of Retinopathy by T2DM.Investigative ophthalmology & visual science · 2025Article
- The Relationship Between Low-Grade Inflammation and Common Femoral Artery Intima-Media Thickness in Newly Diagnosed Type 2 Diabetes Mellitus.Clinical medicine insights. Endocrinology and diabetes · 2025Article
- Long-term prognostic effect of serum albumin concentration in diabetic patients with stable coronary artery disease: A multicenter cohort study.Journal of the Chinese Medical Association : JCMA · 2024Article
- Observational
- Normoglycemia and physiological cortisone level maintain glucose homeostasis in a pancreas-liver microphysiological system.Communications biology · 2024Article
- Baseline and usual triglyceride-glucose index and the risk of chronic kidney disease: a prospective cohort study.GeroScience · 2024Article
- Article
- Serum albumin and cardiovascular disease: a Mendelian randomization study.BMC cardiovascular disorders · 2024Article
- Article
- Inverse association of serum albumin levels with diabetic retinopathy in type 2 diabetic patients: a cross-sectional study.Scientific reports · 2024Article
- Impact of Platelet-to-HDL-Cholesterol Ratio on Long-Term Mortality in Coronary Artery Disease Patients with or Without Type 2 Diabetes: Insights from a Chinese Multicenter Cohort.Journal of inflammation research · 2024Article
- A predictive model for hyperuricemia among type 2 diabetes mellitus patients in Urumqi, China.BMC public health · 2023Article
- Young and undamaged recombinant albumin alleviates T2DM by improving hepatic glycolysis through EGFR and protecting islet β cells in mice.Journal of translational medicine · 2023Article
- Mild cognitive impairment in type 2 diabetes is associated with fibrinogen-to-albumin ratios.PeerJ · 2023Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aims/hypothesisSerum albumin concentrations may be associated with future risk of type 2 diabetes, but the epidemiological evidence is limited and uncertain. We prospectively assessed the association between baseline values of serum albumin and incident type 2 diabetes risk in the Kuopio Ischaemic Heart Disease population-based cohort study.
methodsWe analysed the data of 1,785 men aged 42-61 years with no known history of diabetes at baseline. Participants' serum albumin concentrations were measured at baseline. HRs and 95% CIs for type 2 diabetes events were subsequently assessed.
resultsDuring a mean follow-up of 20.4 years, 382 participants developed diabetes. Serum albumin concentrations were weakly correlated with several established risk factors for diabetes. Serum albumin was approximately linearly associated with type 2 diabetes risk. In analyses adjusted for several conventional risk factors, the HR for type 2 diabetes per 1 SD increase in serum albumin was 1.15 (95% CI 1.03, 1.28; p = 0.016), which persisted after further adjustment for triacylglycerol, C-reactive protein, γ-glutamyltransferase, estimated glomerular filtration rate and total energy intake (HR 1.15; 95% CI 1.02, 1.29; p = 0.018). The findings were generally consistent across several clinical subgroups. Addition of information on serum albumin to a diabetes risk prediction model containing conventional risk factors led to no significant change in C-index (0.0126; 95% CI -0.0055, 0.0306; p = 0.17). CONCLUSIONS/
interpretationA near linear, positive and independent association was found between serum albumin and type 2 diabetes, but this did not improve event discrimination. Further work is warranted to evaluate the causal relevance of these findings.
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