ArticleNeuroImage2015
Invariance in current dipole moment density across brain structures and species: physiological constraint for neuroimaging.
Article in NeuroImage, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 60 citations in OpenAlex.
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- Quantifying Cerebellar Signal Detectability in MEG and EEG in Epilepsy Using Anatomically Informed Source Modeling.bioRxiv : the preprint server for biology · 2026Article
- Computational modeling reveals biological mechanisms underlying the whisker flick EEG.iScience · 2025Article
- High-definition MEG source estimation using the reciprocal boundary element fast multipole method.NeuroImage · 2025Article
- Combined MEG and EEG suggest a limbic source network of the P3 including retrosplenial cortex and hippocampus.bioRxiv : the preprint server for biology · 2025Article
- Stereo-EEG propagating source reconstruction identifies new surgical targets for epilepsy patients.Brain : a journal of neurology · 2025Article
- [Fontanel compensation for infant electroencephalography forward modeling method].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2024Article
- An adaptive h-refinement method for the boundary element fast multipole method for quasi-static electromagnetic modeling.Physics in medicine and biology · 2024Article
- An Adaptive H-Refinement Method for the Boundary Element Fast Multipole Method for Quasi-static Electromagnetic Modeling.bioRxiv : the preprint server for biology · 2023Article
- Relative contributions of different neural sources to the EEG.NeuroImage · 2023Article
- Optimization of patient-specific stereo-EEG recording sensitivity.Brain communications · 2023Article
- Ideal current dipoles are appropriate source representations for simulating neurons for intracranial recordings.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2023Article
- Statistical power: Implications for planning MEG studies.NeuroImage · 2021Article
- Article
- Practical Fundamentals of Clinical MEG Interpretation in Epilepsy.Frontiers in neurology · 2021Review
- Boundary Element Fast Multipole Method for Enhanced Modeling of Neurophysiological Recordings.IEEE transactions on bio-medical engineering · 2021Article
- Parametrizing the Conditionally Gaussian Prior Model for Source Localization with Reference to the P20/N20 Component of Median Nerve SEP/SEF.Brain sciences · 2020Article
- Detectability of cerebellar activity with magnetoencephalography and electroencephalography.Human brain mapping · 2020Article
- Realistic modeling of mesoscopic ephaptic coupling in the human brain.PLoS computational biology · 2020Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Although anatomical constraints have been shown to be effective for MEG and EEG inverse solutions, there are still no effective physiological constraints. Strength of the current generator is normally described by the moment of an equivalent current dipole Q. This value is quite variable since it depends on size of active tissue. In contrast, the current dipole moment density q, defined as Q per surface area of active cortex, is independent of size of active tissue. Here we studied whether the value of q has a maximum in physiological conditions across brain structures and species. We determined the value due to the primary neuronal current (q primary) alone, correcting for distortions due to measurement conditions and secondary current sources at boundaries separating regions of differing electrical conductivities. The values were in the same range for turtle cerebellum (0.56-1.48 nAm/mm(2)), guinea pig hippocampus (0.30-1.34 nAm/mm(2)), and swine neocortex (0.18-1.63 nAm/mm(2)), rat neocortex (~2.2 nAm/mm(2)), monkey neocortex (~0.40 nAm/mm(2)) and human neocortex (0.16-0.77 nAm/mm(2)). Thus, there appears to be a maximum value across the brain structures and species (1-2 nAm/mm(2)). The empirical values closely matched the theoretical values obtained with our independently validated neural network model (1.6-2.8 nAm/mm(2) for initial spike and 0.7-3.1 nAm/mm(2) for burst), indicating that the apparent invariance is not coincidental. Our model study shows that a single maximum value may exist across a wide range of brain structures and species, varying in neuron density, due to fundamental electrical properties of neurons. The maximum value of q primary may serve as an effective physiological constraint for MEG/EEG inverse solutions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.