ReviewJournal of dental research2015
Molecular and clinical aspects of drug-induced gingival overgrowth.
Review in Journal of dental research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
52 citing papers in PubMed, 152 citations in OpenAlex.
- Assessment of Cardiologists' Knowledge, Attitudes, and Practices on Calcium Channel Blocker-Induced Gingival Overgrowth.Oral health & preventive dentistry · 2026Article
- Cyclosporine related adverse events in aplastic anemia patients treated with immunosuppressive therapy.Annals of hematology · 2026Article
- Drug-induced gingival overgrowth: FAERS based real-world pharmacovigilance study and network pharmacology analysis.Frontiers in pharmacology · 2026Article
- Histopathological and Molecular Characterization of Amlodipine-Induced Gingival Enlargement: Insights into Fibrotic Mechanisms.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Single-cell RNA sequencing reveals genes relevant to periodontal therapy and periodontitis.Physiological genomics · 2025Article
- Nonsurgical Management of Drug-induced Gingival Enlargement in a Young Adolescent with Chronic Kidney Disease: A Case Report.International journal of clinical pediatric dentistry · 2025Article
- Drug-associated gingival disorders: a retrospective pharmacovigilance assessment using disproportionality analysis.BDJ open · 2025Article
- Marked Gingival Overgrowth Protruding from the Oral Cavity Due to Sodium Valproate.Diagnostics (Basel, Switzerland) · 2025Article
- Effects of combined cyclosporin and azithromycin treatment on human mononuclear cells under lipopolysaccharide challenge.Frontiers in oral health · 2025Article
- Challenges in Differential Diagnosis of Diffuse Gingival Enlargement: Report of Two Representative Cases and Literature Review.Dentistry journal · 2024Article
- Role of transglutaminase 2 in promoting biglycan synthesis in idiopathic gingival fibromatosis.BMC oral health · 2024Article
- Drugs That Induce Gingival Overgrowth Drive the Pro-Inflammatory Polarization of Macrophages In Vitro.International journal of molecular sciences · 2024Article
- Genetic Variants in theInternational journal of molecular sciences · 2024Article
- Non-surgical Treatment of Severe Drug-Influenced Gingival Enlargement: A Report of Two Cases.Cureus · 2024Article
- Impact of TRP Channels on Extracellular Matrix Remodeling: Focus on TRPV4 and Collagen.International journal of molecular sciences · 2024Review
- Cyclosporine-Induced Gingival Hyperplasia in a Patient With Lichen Planopilaris: Misfortunes Never Come Singly!Cureus · 2023Article
- Expression of epithelial-mesenchymal transition-associated proteins and proliferating cell nuclear antigen in dihydropyridine-induced gingival overgrowth fibroblasts: A preliminary study.Journal of dental sciences · 2023Article
- Drug-Induced Gingival Overgrowth-Molecular Aspects of Drug Actions.International journal of molecular sciences · 2023Review
- Article
- Periodontitis may predict the use of prescription medicines later in life, a database study.Frontiers in pharmacology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Drug-induced gingival overgrowth is a tissue-specific condition and is estimated to affect approximately one million North Americans. Lesions occur principally as side-effects from phenytoin, nifedipine, or ciclosporin therapy in approximately half of the people who take these agents. Due to new indications for these drugs, their use continues to grow. Here, we review the molecular and cellular characteristics of human gingival overgrowth lesions and highlight how they differ considerably as a function of the causative drug. Analyses of molecular signaling pathways in cultured human gingival fibroblasts have provided evidence for their unique aspects compared with fibroblasts from the lung and kidney. These findings provide insights into both the basis for tissue specificity and into possible therapeutic opportunities which are reviewed here. Although ciclosporin-induced gingival overgrowth lesions exhibit principally the presence of inflammation and little fibrosis, nifedipine- and especially phenytoin-induced lesions are highly fibrotic. The increased expression of markers of gingival fibrosis, particularly CCN2 [also known as connective tissue growth factor (CTGF)], markers of epithelial to mesenchymal transition, and more recently periostin and members of the lysyl oxidase family of enzymes have been documented in phenytoin or nifedipine lesions. Some oral fibrotic conditions such as leukoplakia and oral submucous fibrosis, after subsequent additional genetic damage, can develop into oral cancer. Since many pathways are shared, the study of gingival fibrosis and comparisons with characteristics and molecular drivers of oral cancer would likely enhance understandings and functional roles of molecular drivers of these oral pathologies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.