ArticlePloS one2015
The role of hs-CRP, D-dimer and fibrinogen in differentiating etiological subtypes of ischemic stroke.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Trial
- Associations of hs-CRP and D-Dimer with stroke severity and early functional outcomes in ischemic stroke: a retrospective age-stratified cohort study.BMC neurology · 2026Article
- The Immunologic Underpinnings of Post-Stroke Depression.Biological psychiatry global open science · 2025Review
- Serum Biomarkers in Acute Ischemic Stroke: Clinical Applications and Emerging Insights.Journal of clinical medicine · 2025Review
- Stroke Incidence and High-Sensitivity C-Reactive Protein Among African Americans: The Jackson Heart Study.Ethnicity & disease · 2025Article
- Factors influencing the occurrence of ischemic stroke in elderly patients with hypertension and type 2 diabetes mellitus: a case-control study.BMC neurology · 2025Article
- Article
- Inflammation biomarkers in acute ischemic stroke according to different etiologies.European journal of neurology · 2024Article
- Comparison of circulating lipid profiles, D-dimer and fibrinogen levels between hypertensive patients with and without stroke.Metabolism open · 2023Article
- Predictive role of pre-thrombolytic hs-CRP on the safety and efficacy of intravenous thrombolysis in acute ischemic stroke.BMC neurology · 2023Article
- Clinical significance of D-dimer levels during acute period in ischemic stroke.Thrombosis journal · 2023Article
- Blood-Based Biomarkers Are Associated with Different Ischemic Stroke Mechanisms and Enable Rapid Classification between Cardioembolic and Atherosclerosis Etiologies.Diagnostics (Basel, Switzerland) · 2020Review
- Article
- Impact of D-dimer levels for short-term or long-term outcomes in cryptogenic stroke patients.Journal of neurology · 2018Observational
- Article
- Point-of-Care-Testing in Acute Stroke Management: An Unmet Need Ripe for Technological Harvest.Biosensors · 2017Review
- High-sensitivity C-reactive protein in stroke patients - The importance in consideration of influence of multiple factors in the predictability for disease severity and death.Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia · 2017Review
- Update on Inflammatory Biomarkers and Treatments in Ischemic Stroke.International journal of molecular sciences · 2016Review
- Fibrinogen consumption is related to intracranial clot burden in acute ischemic stroke: a retrospective hyperdense artery study.Journal of translational medicine · 2016Article
- MicroRNA-99a-5p in circulating immune cells as a potential biomarker for the early diagnosis of ischemic stroke.Brain circulationArticle
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Authors and funding
5 authors.
Funding
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Abstract
The aim of this study was to evaluate the diagnostic value of the serum biochemical markers high-sensitivity C-reactive protein (hs-CRP), D-dimer (DD) and fibrinogen (Fg) in differentiating etiological subtypes of ischemic stroke. This study was a retrospective case-only study, consecutively including patients with acute ischemic stroke. All patients were classified into subtypes using the TOAST classification system. A total of 317 patients were evaluated. Hs-CRP and DD levels were significantly different among the subtypes and were the highest in CE, followed by LAA and SAA; no significant difference between the subtypes was found for Fg. Hs-CRP > 6.96 mg/L was classified as the CE subtype, with a sensitivity of 41% and a specificity of 74%; DD > 791.30 ng/mL was classified as CE, with a sensitivity of 58% and a specificity of 78%. The combination of hs-CRP and DD classification as CE yielded a sensitivity of 65% and a specificity of 91%. DD > 791.30 ng/mL was considered an independent predictive factor of CE. Hs-CRP and DD could be useful for identifying the etiological subtypes of acute ischemic stroke, especially for predicting CE. The diagnostic value of DD was higher than that of hs-CRP.
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