ArticlePloS one2015
Platelet-rich plasma, especially when combined with a TGF-β inhibitor promotes proliferation, viability and myogenic differentiation of myoblasts in vitro.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Applications of Platelet Concentrates (PCs) in Regenerative Onco-Urology: A Systematic Review of Literature.International journal of molecular sciences · 2024Pooled it
- Effect of Bone Marrow Aspirate Concentrate-Platelet-Rich Plasma on Tendon-Derived Stem Cells and Rotator Cuff Tendon Tear.Cell transplantation · 2017Trial
- Effects of platelet-rich plasma on cutaneous flap healing in rabbits: a pilot comparative experimental study with adipose tissue.Scientific reports · 2026Article
- Therapeutic strategies to modulate gut microbial health: Approaches for sarcopenia management.Histology and histopathology · 2024Review
- Characteristics of bovine muscle satellite cell from different breeds for efficient production of cultured meat.Journal of animal science and technology · 2024Article
- Platelet-Rich Plasma Promotes the Expansion of Human Myoblasts and Favors the In Vitro Generation of Human Muscle Reserve Cells in a Deeper State of Quiescence.Stem cell reviews and reports · 2024Article
- The application of bone marrow mesenchymal stem cells and biomaterials in skeletal muscle regeneration.Regenerative therapy · 2020Review
- Transcriptomic Profile of Primary Culture of Skeletal Muscle Cells Isolated from Semitendinosus Muscle of Beef and Dairy Bulls.International journal of molecular sciences · 2020Article
- Platelet-rich plasma for muscle injuries: A systematic review of the basic science literature.World journal of orthopedics · 2019Article
- Influence of Platelet-Rich and Platelet-Poor Plasma on Endogenous Mechanisms of Skeletal Muscle Repair/Regeneration.International journal of molecular sciences · 2019Review
- Platelet-rich plasma does not reduce skeletal muscle fibrosis after distraction osteogenesis.Journal of experimental orthopaedics · 2018Article
- Nonoperative treatment of muscle injuries - recommendations from the GOTS expert meeting.Journal of experimental orthopaedics · 2018Review
- Human serum and platelet lysate are appropriate xeno-free alternatives for clinical-grade production of human MuStem cell batches.Stem cell research & therapy · 2018Article
- Concise Review: Stem Cell Fate Guided By Bioactive Molecules for Tendon Regeneration.Stem cells translational medicine · 2018Review
- Platelet-rich plasma: combinational treatment modalities for musculoskeletal conditions.Frontiers of medicine · 2018Review
- Immunology Guides Skeletal Muscle Regeneration.International journal of molecular sciences · 2018Review
- Analysis of photobiomodulation associated or not with platelet-rich plasma on repair of muscle tissue by Raman spectroscopy.Lasers in medical science · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Regeneration of skeletal muscle after injury is limited by scar formation, slow healing time and a high recurrence rate. A therapy based on platelet-rich plasma (PRP) has become a promising lead for tendon and ligament injuries in recent years, however concerns have been raised that PRP-derived TGF-β could contribute to fibrotic remodelling in skeletal muscle after injury. Due to the lack of scientific grounds for a PRP -based muscle regeneration therapy, we have designed a study using human myogenic progenitors and evaluated the potential of PRP alone and in combination with decorin (a TGF-β inhibitor), to alter myoblast proliferation, metabolic activity, cytokine profile and expression of myogenic regulatory factors (MRFs). Advanced imaging multicolor single-cell analysis enabled us to create a valuable picture on the ratio of quiescent, activated and terminally committed myoblasts in treated versus control cell populations. Finally high-resolution confocal microscopy validated the potential of PRP and decorin to stimulate the formation of polynucleated myotubules. PRP was shown to down-regulate fibrotic cytokines, increase cell viability and proliferation, enhance the expression of MRFs, and contribute to a significant myogenic shift during differentiation. When combined with decorin further synergistc effects were identified. These results suggest that PRP could not only prevent fibrosis but could also stimulate muscle commitment, especially when combined with a TGF-β inhibitor.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.