ArticlePhysical review letters2015
Multiscale polar theory of microtubule and motor-protein assemblies.
Article in Physical review letters, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed.
- Feedback between filament spacing, crosslinker binding, and self-organization in cytoskeletal bundles.bioRxiv : the preprint server for biology · 2026Article
- Form and function in biological filaments: a physicist's review.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2025Review
- Synthetic Active Liquid Crystals Powered by Acoustic Waves.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Asymmetric fluctuations and self-folding of active interfaces.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Kinesin-5/Cut7 C-terminal tail phosphorylation is essential for microtubule sliding force and bipolar mitotic spindle assembly.Current biology : CB · 2024Article
- Structure and dynamics of motor-driven microtubule bundles.Soft matter · 2024Article
- Motor crosslinking augments elasticity in active nematics.Soft matter · 2024Article
- Microscopic interactions control a structural transition in active mixtures of microtubules and molecular motors.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Spatio-temporal patterning of extensile active stresses in microtubule-based active fluids.PNAS nexus · 2023Article
- Spontaneous phase coordination and fluid pumping in model ciliary carpets.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Self-mixing in microtubule-kinesin active fluid from nonuniform to uniform distribution of activity.Nature communications · 2022Article
- Competing instabilities reveal how to rationally design and control active crosslinked gels.Nature communications · 2022Article
- Multiscale architecture: Mechanics of composite cytoskeletal networks.Biophysics reviews · 2022Review
- Article
- Modeling spatiotemporally varying protein-protein interactions in CyLaKS, the Cytoskeleton Lattice-based Kinetic Simulator.The European physical journal. E, Soft matter · 2021Article
- Active liquid crystals powered by force-sensing DNA-motor clusters.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Flow coupling between active and passive fluids across water-oil interfaces.Scientific reports · 2021Article
- Comparison of explicit and mean-field models of cytoskeletal filaments with crosslinking motors.The European physical journal. E, Soft matter · 2021Article
- Filamentous active matter: Band formation, bending, buckling, and defects.Science advances · 2020Article
- Article
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Authors and funding
5 authors.
Funding
Abstract
Microtubules and motor proteins are building blocks of self-organized subcellular biological structures such as the mitotic spindle and the centrosomal microtubule array. These same ingredients can form new "bioactive" liquid-crystalline fluids that are intrinsically out of equilibrium and which display complex flows and defect dynamics. It is not yet well understood how microscopic activity, which involves polarity-dependent interactions between motor proteins and microtubules, yields such larger-scale dynamical structures. In our multiscale theory, Brownian dynamics simulations of polar microtubule ensembles driven by cross-linking motors allow us to study microscopic organization and stresses. Polarity sorting and cross-link relaxation emerge as two polar-specific sources of active destabilizing stress. On larger length scales, our continuum Doi-Onsager theory captures the hydrodynamic flows generated by polarity-dependent active stresses. The results connect local polar structure to flow structures and defect dynamics.
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