ArticleEye (London, England)2015
Blood-aqueous barrier integrity in patients with Graves' ophthalmopathy (GO), before and after rehabilitative surgery.
Article in Eye (London, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 6 citations in OpenAlex.
- Using 24-h intraocular pressure-related patterns to identify open-angle glaucoma in thyroid eye disease.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2023Trial
- Reduced-Order Model for Cell Volume Homeostasis: Application to Aqueous Humor Production.Mathematical & computational applications · 2025Article
- Evaluation of Aqueous Flare in Graves' Ophthalmopathy and its Relationship with Thyroid Hormones, Antibodies, and Clinical Activity Score.Beyoglu eye journal · 2023Article
- Laser flare-cell photometer: principle and significance in clinical and basic ophthalmology.Japanese journal of ophthalmology · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
purposeThe study was conducted to analyze aqueous flare and its correlations in patients with Graves' ophthalmopathy (GO) undergoing orbital decompression, extraocular muscle, and eyelid surgery. Prospective interventional case series. PATIENTS AND
methodsForty-eight eyes of 27 patients (20 female and 7 male, aged 54.4 ± 5.7) undergoing surgical treatment for GO. Eighteen eyes of nine patients (aged 55.3 ± 3.6) undergoing orbital decompression. Nineteen eyes of 11 patients (aged 54.7 ± 5.6) undergoing extraocular muscle surgery and 13 eyes of 7 patients (aged 53.9 ± 4.9) undergoing eyelid surgery and control group (34 patients aged 53.9 ± 5.1). Laser flare analysis and clinical assessment were performed before surgery and at 1 day, 7 days, and 3 months following surgery.
resultsAqueous flare was significantly higher in patients with GO (14.03 ± 8.45) before intervention than in the control group (7.89 ± 3.56) (P<0.001), and correlated with Clinical Activity Score and intraocular pressure. In the patients undergoing orbital decompression, flare increased from 17.77 ± 10.63 pc/ms to 38.32 ± 13.56 pc/ms on the first day and 41.31 ± 17.19 pc/ms on the seventh day and returned to 16.01 ± 8.58 pc/ms in 3 months. In patients undergoing extraocular muscle surgery flare increased from 13.05 ± 6.50 to 23.04 ± 11.53 pc/ms (P<0.001) on the first day and returned to 18.02 ± 14.09 pc/ms on the seventh day. Eyelid surgery did not change flare values.
conclusionsOrbital decompression disrupts blood-aqueous barrier (BAB). The integrity of BAB returns to preoperative status within 3 months. Extraocular muscle surgery mildly affects BAB integrity, and the effect subsides within 7 days. Eyelid surgery does not affect BAB.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.