ArticlePloS one2015
Glycation of human cortical and cancellous bone captures differences in the formation of Maillard reaction products between glucose and ribose.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 48 citations in OpenAlex.
- Identification of water compartment in bone using ATR-FTIR spectroscopy.Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy · 2026Article
- Glycoxidation of the bone matrix modulates mineralization.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2025Article
- Ribosylation-induced increase in advanced glycation end products has limited impacts on mechanical properties in human cortical bone.Bone reports · 2025Article
- Changes in Gene Expression Patterns in Young and Senescent Fibroblasts in Glycated Three-Dimensional Collagen Matrices.International journal of molecular sciences · 2025Article
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- Non-enzymatic glycation reduces glucose transport in the human cartilage endplate independently of matrix porosity or proteoglycan content.JOR spine · 2024Article
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- Effect of non-enzymatic glycation on collagen nanoscale mechanisms in diabetic and age-related bone fragility.Biocell : official journal of the Sociedades Latinoamericanas de Microscopia Electronica ... et. al · 2023Article
- Type 2 diabetes alters the viscoelastic behavior and macromolecular composition of vertebra.Bone reports · 2023Article
- Preventing Disused Bone Loss through Inhibition of Advanced Glycation End Products.International journal of molecular sciences · 2023Article
- Structural role of osteocalcin and its modification in bone fracture.Applied physics reviews · 2023Article
- Advanced Glycation End Products and Bone Metabolism in Patients with Chronic Kidney Disease.JBMR plus · 2023Article
- Degradation of Bone Quality in a Transgenic Mouse Model of Alzheimer's Disease.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022Article
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- Non-Obese MKR Mouse Model of Type 2 Diabetes Reveals Skeletal Alterations in Mineralization and Material Properties.JBMR plus · 2022Article
- Controlled Formation of Carboxymethyllysine in Bone Matrix through Designed Glycation Reaction.JBMR plus · 2021Article
- Circadian rhythm disruption with high-fat diet impairs glycemic control and bone quality.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Article
- Reinforced Universal Adhesive by Ribose Crosslinker: A Novel Strategy in Adhesive Dentistry.Polymers · 2021Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
To better understand some aspects of bone matrix glycation, we used an in vitro glycation approach. Within two weeks, our glycation procedures led to the formation of advanced glycation end products (AGEs) at the levels that corresponded to approx. 25-30 years of the natural in vivo glycation. Cortical and cancellous bones from human tibias were glycated in vitro using either glucose (glucosylation) or ribose (ribosylation). Both glucosylation and ribosylation led to the formation of higher levels of AGEs and pentosidine (PEN) in cancellous than cortical bone dissected from all tested donors (young, middle-age and elderly men and women). More efficient glycation of bone matrix proteins in cancellous bone most likely depended on the higher porosity of this tissue, which facilitated better accessibility of the sugars to the matrix proteins. Notably, glycation of cortical bone from older donors led to much higher AGEs levels as compared to young donors. Such efficient in vitro glycation of older cortical bone could result from aging-related increase in porosity caused by the loss of mineral content. In addition, more pronounced glycation in vivo would be driven by elevated oxidation processes. Interestingly, the levels of PEN formation differed pronouncedly between glucosylation and ribosylation. Ribosylation generated very high levels of PEN (approx. 6- vs. 2.5-fold higher PEN level than in glucosylated samples). Kinetic studies of AGEs and PEN formation in human cortical and cancellous bone matrix confirmed higher accumulation of fluorescent crosslinks for ribosylation. Our results suggest that in vitro glycation of bone using glucose leads to the formation of lower levels of AGEs including PEN, whereas ribosylation appears to support a pathway toward PEN formation. Our studies may help to understand differences in the progression of bone pathologies related to protein glycation by different sugars, and raise awareness for excessive sugar supplementation in food and drinks.
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