Evidence map›Paper›PMID 25678985›Full record

ArticleCurrent addiction reports2014

Recent Translational Findings on Impulsivity in Relation to Drug Abuse.

Jessica Weafer, Suzanne H Mitchell, Harriet de Wit

Open access · bronzeAbstract read
In one paragraph

Article in Current addiction reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 4 pooled it
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 4 syntheses or guidelines pooled it, 128 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Jessica WeaferDepartment of Psychiatry and Behavioral Neuroscience, University of Chicago, 5841 S. Maryland Avenue MC3077, Chicago, IL 60637, USA.
Suzanne H MitchellDepartments of Behavioral Neuroscience and Psychiatry, L470, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA.
Harriet de WitDepartment of Psychiatry and Behavioral Neuroscience, University of Chicago, 5841 S. Maryland Avenue MC3077, Chicago, IL 60637, USA.
University of Chicago · USOregon Health & Science University · US

Funding

Translational measures of risk for excessive alcohol consumptionP60AA010760 · NIAAA · OREGON HEALTH & SCIENCE UNIVERSITY · PI Suzanne S. Fei · 2006 to 2026
$34.5M
Re-Engineering Translational Research at the University of ChicagoUL1TR000430 · NCATS · UNIVERSITY OF CHICAGO · PI SOLWAY, JULIAN · 2012 to 2016
$20.2M
THERMAL AND METABOLIC DYSFUNCTION DURING WITHDRAWALP50AA010760 · NIAAA · OREGON HEALTH AND SCIENCE UNIVERSITY · PI CRABBE, JOHN C. · 1996 to 2005
$10.7M
Determinants of Drug Preference in Humans--Administrative SupplementR01DA002812 · NIDA · UNIVERSITY OF CHICAGO · PI DE WIT, HARRIET · 1985 to 2024
$10.6M
The genetic basis of impulsive behavior in humansR01DA032015 · NIDA · UNIVERSITY OF CHICAGO · PI DE WIT, HARRIET · 2011 to 2015
$2.4M
Impulsivity and Stimulant Drug RewardF32DA033756 · NIDA · UNIVERSITY OF CHICAGO · PI WEAFER, JESSICA J · 2012 to 2014
$130k
NCATS NIH HHS UL1 TR000430NIAAA NIH HHS P50 AA010760NIAAA NIH HHS P60 AA010760NIDA NIH HHS F32 DA033756NIDA NIH HHS R01 DA002812NIDA NIH HHS R01 DA032015
6 · The paper itself

Abstract

Impulsive behavior is strongly implicated in drug abuse, as both a cause and a consequence of drug use. To understand how impulsive behaviors lead to and result from drug use, translational evidence from both human and non-human animal studies is needed. Here, we review recent (2009 or later) studies that have investigated two major components of impulsive behavior, inhibitory control and impulsive choice, across preclinical and clinical studies. We concentrate on the stop-signal task as the measure of inhibitory control and delay discounting as the measure of impulsive choice. Consistent with previous reports, recent studies show greater impulsive behavior in drug users compared with non-users. Additionally, new evidence supports the prospective role of impulsive behavior in drug abuse, and has begun to identify the neurobiological mechanisms underlying impulsive behavior. We focus on the commonalities and differences in findings between preclinical and clinical studies, and suggest future directions for translational research.

Indexed as

Delay discountingDrug abuseImpulsive behaviorImpulsive choiceInhibitory controlStop-signal task

Identifiers

PMID25678985
PMCPMC4323183
OpenAlexW2083911844

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.