ArticleClinical proteomics2015
Proteomic signatures of serum albumin-bound proteins from stroke patients with and without endovascular closure of PFO are significantly different and suggest a novel mechanism for cholesterol efflux.
Article in Clinical proteomics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 40 citations in OpenAlex.
- Trial
- A whole-exome sequencing study of patent foramen ovale: investigating genetic variants and their association with cardiovascular disorders.Frontiers in genetics · 2024Article
- Proteomic advance of ischemic stroke: preclinical, clinical, and intervention.Metabolic brain disease · 2023Review
- Recent progress in patent foramen ovale and related neurological diseases: A narrative review.Frontiers in neurology · 2023Review
- Raman Spectroscopy of Carotenoid Compounds for Clinical Applications-A Review.Molecules (Basel, Switzerland) · 2022Review
- A Prospective, Single-Center, Phase I Clinical Trial to Evaluate the Value of Transesophageal Echocardiography in the Closure of Patent Foramen Ovale With a Novel Biodegradable Occluder.Frontiers in cardiovascular medicine · 2022Article
- Article
- Residual Shunt After Patent Foramen Ovale Closure and Long-Term Stroke Recurrence: A Prospective Cohort Study.Annals of internal medicine · 2020Article
- Clinical and infarction patterns of PFO-related cryptogenic strokes and a prediction model.Annals of clinical and translational neurology · 2018Article
- Opposing activities of oncogenic MIR17HG and tumor suppressive MIR100HG clusters and their gene targets regulate replicative senescence in human adult stem cells.NPJ aging and mechanisms of disease · 2017Article
- The association between MMP-12 82 A/G polymorphism and susceptibility to various malignant tumors: a meta-analysis.International journal of clinical and experimental medicine · 2015Article
- Macrophage infiltration promotes invasiveness of breast cancer cells via activating long non-coding RNA UCA1.International journal of clinical and experimental pathology · 2015Article
- Dysfunctional High-Density Lipoprotein: An Innovative Target for Proteomics and Lipidomics.Cholesterol · 2015Review
- Association between plasma homocysteine and progression of early nephropathy in type 2 diabetic patients.International journal of clinical and experimental medicine · 2015Article
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Authors and funding
18 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe anatomy of PFO suggests that it can allow thrombi and potentially harmful circulatory factors to travel directly from the venous to the arterial circulation - altering circulatory phenotype. Our previous publication using high-resolution LC-MS/MS to profile protein and peptide expression patterns in plasma showed that albumin was relatively increased in donor samples from PFO-related than other types of ischemic strokes. Since albumin binds a host of molecules and acts as a carrier for lipoproteins, small molecules and drugs, we decided to investigate the albumin-bound proteins (in a similar sample cohort) in an effort to unravel biological changes and potentially discover biomarkers related to PFO-related stroke and PFO endovascular closure.
methodsThe method used in this study combined albumin immuno-enrichment with high resolution LC-MS in order to specifically capture and quantify the albumin-bound proteins. Subsequently, we measured cholesterol and HDL in a larger, separate cohort of PFO stroke patients, pre and post closure.
resultsThe results demonstrated that a number of proteins were specifically associated with albumin in samples with and without endovascular closure of the PFO, and that the protein profiles were very different. Eight proteins, typically associated with HDL were common to both sample sets and quantitatively differently abundant. Pathway analysis of the MS results suggested that enhanced cholesterol efflux and reduced lipid oxidation were associated with PFO closure. Measurement of total cholesterol and HDL in a larger cohort of PFO closure samples using a colorimetric assay was consistent with the proteomic predictions.
conclusionsThe collective data presented in this study demonstrate that analysis of albumin-bound proteins could provide a valuable tool for biomarker discovery on the effects of PFO endovascular closure. In addition, the results suggest that PFO endovascular closure can potentially have effects on HDL, cholesterol and albumin-bound ApoA-I abundance, therefore possibly providing benefits in cardioprotective functions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.