Evidence map›Paper›PMID 25678625›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2015

Glucagon-like peptide-1 is specifically involved in sweet taste transmission.

Shingo Takai, Keiko Yasumatsu, Mayuko Inoue, Shusuke Iwata, Ryusuke Yoshida, Noriatsu Shigemura, Yuchio Yanagawa, Daniel J Drucker, Robert F Margolskee, Yuzo Ninomiya

Abstract read
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In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed
5.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 94 citations in OpenAlex.

  1. GLP-1 Receptor Agonists and Weight Loss: A Critical Review of Mechanisms.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026
    Review
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  14. Mechanisms and Functions of Sweet Reception in Oral and Extraoral Organs.International journal of molecular sciences · 2024
    Review
  15. Review
  16. Article
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  18. Article
  19. Endocrinology of Taste with Aging.Endocrinology and metabolism clinics of North America · 2023
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 3 countries.

Shingo Takai*Section of Oral Neuroscience, Graduate School of Dental Sciences, Kyushu University, Fukuoka, Japan; Division of Sensory Physiology, Research and Development Center for Taste and Odor Sensing, Kyushu University, Fukuoka, Japan; Department of Genetic and Behavioral Neuroscience, Gunma University Graduate School of Medicine, and JST, CREST, Maebashi, Japan; The Lunenfeld Tanenbaum Research Institute, Mt. Sinai Hospital, University of Toronto, Toronto, Ontario, Canada; and Monell Chemical Senses Center, Philadelphia, Pennsylvania, USA.
Keiko Yasumatsu*Section of Oral Neuroscience, Graduate School of Dental Sciences, Kyushu University, Fukuoka, Japan; Division of Sensory Physiology, Research and Development Center for Taste and Odor Sensing, Kyushu University, Fukuoka, Japan; Department of Genetic and Behavioral Neuroscience, Gunma University Graduate School of Medicine, and JST, CREST, Maebashi, Japan; The Lunenfeld Tanenbaum Research Institute, Mt. Sinai Hospital, University of Toronto, Toronto, Ontario, Canada; and Monell Chemical Senses Center, Philadelphia, Pennsylvania, USA.
Mayuko Inoue*Section of Oral Neuroscience, Graduate School of Dental Sciences, Kyushu University, Fukuoka, Japan; Division of Sensory Physiology, Research and Development Center for Taste and Odor Sensing, Kyushu University, Fukuoka, Japan; Department of Genetic and Behavioral Neuroscience, Gunma University Graduate School of Medicine, and JST, CREST, Maebashi, Japan; The Lunenfeld Tanenbaum Research Institute, Mt. Sinai Hospital, University of Toronto, Toronto, Ontario, Canada; and Monell Chemical Senses Center, Philadelphia, Pennsylvania, USA.
Shusuke Iwata*Section of Oral Neuroscience, Graduate School of Dental Sciences, Kyushu University, Fukuoka, Japan; Division of Sensory Physiology, Research and Development Center for Taste and Odor Sensing, Kyushu University, Fukuoka, Japan; Department of Genetic and Behavioral Neuroscience, Gunma University Graduate School of Medicine, and JST, CREST, Maebashi, Japan; The Lunenfeld Tanenbaum Research Institute, Mt. Sinai Hospital, University of Toronto, Toronto, Ontario, Canada; and Monell Chemical Senses Center, Philadelphia, Pennsylvania, USA.
Ryusuke Yoshida*Section of Oral Neuroscience, Graduate School of Dental Sciences, Kyushu University, Fukuoka, Japan; Division of Sensory Physiology, Research and Development Center for Taste and Odor Sensing, Kyushu University, Fukuoka, Japan; Department of Genetic and Behavioral Neuroscience, Gunma University Graduate School of Medicine, and JST, CREST, Maebashi, Japan; The Lunenfeld Tanenbaum Research Institute, Mt. Sinai Hospital, University of Toronto, Toronto, Ontario, Canada; and Monell Chemical Senses Center, Philadelphia, Pennsylvania, USA.
Noriatsu Shigemura*Section of Oral Neuroscience, Graduate School of Dental Sciences, Kyushu University, Fukuoka, Japan; Division of Sensory Physiology, Research and Development Center for Taste and Odor Sensing, Kyushu University, Fukuoka, Japan; Department of Genetic and Behavioral Neuroscience, Gunma University Graduate School of Medicine, and JST, CREST, Maebashi, Japan; The Lunenfeld Tanenbaum Research Institute, Mt. Sinai Hospital, University of Toronto, Toronto, Ontario, Canada; and Monell Chemical Senses Center, Philadelphia, Pennsylvania, USA.
Yuchio Yanagawa*Section of Oral Neuroscience, Graduate School of Dental Sciences, Kyushu University, Fukuoka, Japan; Division of Sensory Physiology, Research and Development Center for Taste and Odor Sensing, Kyushu University, Fukuoka, Japan; Department of Genetic and Behavioral Neuroscience, Gunma University Graduate School of Medicine, and JST, CREST, Maebashi, Japan; The Lunenfeld Tanenbaum Research Institute, Mt. Sinai Hospital, University of Toronto, Toronto, Ontario, Canada; and Monell Chemical Senses Center, Philadelphia, Pennsylvania, USA.
Daniel J Drucker*Section of Oral Neuroscience, Graduate School of Dental Sciences, Kyushu University, Fukuoka, Japan; Division of Sensory Physiology, Research and Development Center for Taste and Odor Sensing, Kyushu University, Fukuoka, Japan; Department of Genetic and Behavioral Neuroscience, Gunma University Graduate School of Medicine, and JST, CREST, Maebashi, Japan; The Lunenfeld Tanenbaum Research Institute, Mt. Sinai Hospital, University of Toronto, Toronto, Ontario, Canada; and Monell Chemical Senses Center, Philadelphia, Pennsylvania, USA.
Robert F Margolskee*Section of Oral Neuroscience, Graduate School of Dental Sciences, Kyushu University, Fukuoka, Japan; Division of Sensory Physiology, Research and Development Center for Taste and Odor Sensing, Kyushu University, Fukuoka, Japan; Department of Genetic and Behavioral Neuroscience, Gunma University Graduate School of Medicine, and JST, CREST, Maebashi, Japan; The Lunenfeld Tanenbaum Research Institute, Mt. Sinai Hospital, University of Toronto, Toronto, Ontario, Canada; and Monell Chemical Senses Center, Philadelphia, Pennsylvania, USA.
Yuzo Ninomiya*Section of Oral Neuroscience, Graduate School of Dental Sciences, Kyushu University, Fukuoka, Japan; Division of Sensory Physiology, Research and Development Center for Taste and Odor Sensing, Kyushu University, Fukuoka, Japan; Department of Genetic and Behavioral Neuroscience, Gunma University Graduate School of Medicine, and JST, CREST, Maebashi, Japan; The Lunenfeld Tanenbaum Research Institute, Mt. Sinai Hospital, University of Toronto, Toronto, Ontario, Canada; and Monell Chemical Senses Center, Philadelphia, Pennsylvania, USA ninomoiya.yuzo.285@m.kyushu-u.ac.jp.
Kyushu Dental University · JPKyushu University · JPGunma University · JPLunenfeld-Tanenbaum Research Institute · CAMonell Chemical Senses Center · USSenshu University · JP

Funding

The Role of T1r Taste Receptors in GustationR01DC003155 · NIDCD · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI MARGOLSKEE, ROBERT F. · 1998 to 2014
$5.2M
GUSTDUCIN PHOSPHODIESTERASE INTERACTION IN GUSTATIONR01DC003055 · NIDCD · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI MARGOLSKEE, ROBERT F. · 1996 to 2013
$4.6M
Molecular BiologyP30DC011735 · NIDCD · MONELL CHEMICAL SENSES CENTER · PI HUANG, LIQUAN · 2011 to 2015
$2.5M
Pathways and genes of sweet taste cellsR01DC014105 · NIDCD · MONELL CHEMICAL SENSES CENTER · PI MARGOLSKEE, ROBERT F. · 2015 to 2019
$1.6M
NIDCD NIH HHS P30 DC011735NIDCD NIH HHS R01 DC003055NIDCD NIH HHS R01 DC003155NIDCD NIH HHS R01 DC014105
6 · The paper itself

Abstract

Five fundamental taste qualities (sweet, bitter, salty, sour, umami) are sensed by dedicated taste cells (TCs) that relay quality information to gustatory nerve fibers. In peripheral taste signaling pathways, ATP has been identified as a functional neurotransmitter, but it remains to be determined how specificity of different taste qualities is maintained across synapses. Recent studies demonstrated that some gut peptides are released from taste buds by prolonged application of particular taste stimuli, suggesting their potential involvement in taste information coding. In this study, we focused on the function of glucagon-like peptide-1 (GLP-1) in initial responses to taste stimulation. GLP-1 receptor (GLP-1R) null mice had reduced neural and behavioral responses specifically to sweet compounds compared to wild-type (WT) mice. Some sweet responsive TCs expressed GLP-1 and its receptors were expressed in gustatory neurons. GLP-1 was released immediately from taste bud cells in response to sweet compounds but not to other taste stimuli. Intravenous administration of GLP-1 elicited transient responses in a subset of sweet-sensitive gustatory nerve fibers but did not affect other types of fibers, and this response was suppressed by pre-administration of the GLP-1R antagonist Exendin-4(3-39). Thus GLP-1 may be involved in normal sweet taste signal transmission in mice.

Indexed as

Signal TransductionTasteAmilorideAnimalsChorda Tympani NerveEnzyme-Linked Immunosorbent AssayExenatideGlucagon-Like Peptide 1Glucagon-Like Peptide-1 ReceptorHydrochloric AcidMice, Inbred C57BLMice, KnockoutMice, TransgenicMicroscopy, ConfocalNeuronsPeptidesAmilorideExenatideGlp1r protein, mouseGlucagon-Like Peptide 1Glucagon-Like Peptide-1 ReceptorHydrochloric AcidPeptidesQuinineReceptors, GlucagonSaccharinSodium ChlorideSucroseVenomsgustationincretintransmitter

Identifiers

PMID25678625
PMCPMC4763871
OpenAlexW2171882839

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.