ReviewMicrobial biotechnology2015
Genetic characterization of caffeine degradation by bacteria and its potential applications.
Review in Microbial biotechnology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 99 citations in OpenAlex.
- Growth ofBiomolecules · 2026Article
- Microbial mechanisms as tools for monitoring and treating emerging contaminants in urban pollution: an overview.Archives of microbiology · 2026Review
- Transcriptomic Insights into Caffeine Degradation Pathways inMicroorganisms · 2025Article
- Channel Geometry Controls on Chemical Behavior in Rivers: Insights from a Comparative Field Study.ACS ES&T water · 2025Article
- Application of Microbial Fermentation in Caffeine Degradation and Flavor Modulation of Coffee Beans.Foods (Basel, Switzerland) · 2025Review
- Progress in Methylxanthine Biosynthesis: Insights into Pathways and Engineering Strategies.International journal of molecular sciences · 2025Review
- Unearthing Lactococcus lactis and Scheffersomyeces symbionts from edible wood-boring beetle larvae as a bio-resource for industrial applications.BMC microbiology · 2024Article
- Model-driven characterization of functional diversity ofMicrobial genomics · 2024Article
- Exploring the Evolvability of Plant Specialized Metabolism: Uniqueness Out Of Uniformity and Uniqueness Behind Uniformity.Plant & cell physiology · 2023Review
- Mining cancer genomes for change-of-metabolic-function mutations.Communications biology · 2023Article
- Analyzing microbial communities and their biodegradation of multiple pharmaceuticals in membrane bioreactors.Applied microbiology and biotechnology · 2023Article
- Human metabolome variation along the upper intestinal tract.Nature metabolism · 2023Article
- Biomarkers selection for population normalization in SARS-CoV-2 wastewater-based epidemiology.Water research · 2022Article
- Biomarkers Selection for Population Normalization in SARS-CoV-2 Wastewater-based Epidemiology.medRxiv : the preprint server for health sciences · 2022Article
- Bacterial and fungal communities within and among geographic samples of the hemp pestFrontiers in microbiology · 2022Article
- Urate oxidase from tea microbeFrontiers in nutrition · 2022Article
- Microbial Degradation of Caffeine Using Himalayan Psychrotolerant Pseudomonas sp.GBPI_Hb5 (MCC 3295).Current microbiology · 2021Article
- Cultivation and Genome Sequencing of Bacteria Isolated From the Coffee Berry Borer (Frontiers in microbiology · 2021Article
- Distinct Changes Occur in the Human Breast Milk Microbiome Between Early and Established Lactation in Breastfeeding Guatemalan Mothers.Frontiers in microbiology · 2021Article
- Occurrence, fate, persistence and remediation of caffeine: a review.Environmental science and pollution research international · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ability of bacteria to grow on caffeine as sole carbon and nitrogen source has been known for over 40 years. Extensive research into this subject has revealed two distinct pathways, N-demethylation and C-8 oxidation, for bacterial caffeine degradation. However, the enzymological and genetic basis for bacterial caffeine degradation has only recently been discovered. This review article discusses the recent discoveries of the genes responsible for both N-demethylation and C-8 oxidation. All of the genes for the N-demethylation pathway, encoding enzymes in the Rieske oxygenase family, reside on 13.2-kb genomic DNA fragment found in Pseudomonas putida CBB5. A nearly identical DNA fragment, with homologous genes in similar orientation, is found in Pseudomonas sp. CES. Similarly, genes for C-8 oxidation of caffeine have been located on a 25.2-kb genomic DNA fragment of Pseudomonas sp. CBB1. The C-8 oxidation genes encode enzymes similar to those found in the uric acid metabolic pathway of Klebsiella pneumoniae. Various biotechnological applications of these genes responsible for bacterial caffeine degradation, including bio-decaffeination, remediation of caffeine-contaminated environments, production of chemical and fuels and development of diagnostic tests have also been demonstrated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.