ArticleMovement disorders : official journal of the Movement Disorder Society2015
Effect of neurostimulation on camptocormia in Parkinson's disease depends on symptom duration.
Article in Movement disorders : official journal of the Movement Disorder Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.
- Deep brain stimulation for Parkinson's disease-related postural abnormalities: a systematic review and meta-analysis.Neurosurgical review · 2022Pooled it
- Efficacy and safety ofBMC neurology · 2026Trial
- The Study of Subthalamic Deep Brain Stimulation for Parkinson Disease-Associated Camptocormia.Medical science monitor : international medical journal of experimental and clinical research · 2020Trial
- Central Pathophysiology and Brain Network Changes Related to Camptocormia in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2025Article
- Camptocormia in Parkinson's disease: state of the art and future directions.Journal of neurology · 2025Review
- Integrative Postural Rehabilitation for Kyphotic Deformity in a Patient with Parkinson's Disease: A Case Report and Literature Review.Journal of clinical medicine · 2025Article
- Spinal cord stimulation for postural abnormalities in Parkinson's disease: 1-year prospective pilot study.BMC neurology · 2024Article
- Treatment of axial postural abnormalities in parkinsonism disorders: A systematic review of pharmacological, rehabilitative and surgical interventions.Clinical parkinsonism & related disorders · 2024Article
- Botulinum toxin therapy in Parkinson disease-related lower limb dystonia. An 8 year retrospective review.Clinical parkinsonism & related disorders · 2024Article
- Impact of deep brain stimulation therapy on the vertebral sagittal balance in Parkinson's disease patients.Neurosurgical review · 2023Article
- Does Impaired Plantar Cutaneous Vibration Perception Contribute to Axial Motor Symptoms in Parkinson's Disease? Effects of Medication and Subthalamic Nucleus Deep Brain Stimulation.Brain sciences · 2023Article
- Article
- Article
- Characterizing Camptocormia in Parkinson's Disease Using Muscle Ultrasonography.Journal of Parkinson's disease · 2023Article
- Pallidal stimulation as treatment for camptocormia in Parkinson's disease.NPJ Parkinson's disease · 2021Article
- Deep brain stimulation in the subthalamic nuclei alters postural alignment and adaptation in Parkinson's disease.PloS one · 2021Article
- Effect of Subthalamic Nucleus Deep Brain Stimulation (STN-DBS) on balance performance in Parkinson's disease.PloS one · 2020Article
- Effects of Deep Brain Stimulation on Postural Trunk Deformities: A Systematic Review.Movement disorders clinical practice · 2019Review
- Height and weight changes after deep brain stimulation in patients with Parkinson disease: role of clinical subtypes.Heliyon · 2019Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although some reports on neurostimulation are positive, no effective treatment method for camptocormia in Parkinson's disease (PD) is known to date. We aim to identify prognostic factors for a beneficial DBS effect on camptocormia. In an observational cohort study, we investigated 25 idiopathic PD patients, who suffered additionally from camptocormia, and underwent bilateral neurostimulation of the subthalamic nucleus (STN) to improve classical PD symptoms. Using an established questionnaire, we examined deep brain stimulation (DBS) effects on camptocormia in addition to general neurostimulation effects. A beneficial neurostimulation effect on camptocormia was defined as an improvement in the bending angle of a least 50%. In 13 patients, the bending angle of camptocormia improved, in 12 patients it did not. A multifactorial analysis revealed a short duration between onset of camptocormia and start of neurostimulation to be the relevant factor for outcome. All patients with duration of camptocormia up to 1.5 years showed a beneficial effect; patients between 1.5 and ∼3 years showed mixed results, but none with a duration of more than 40 months improved except for 1 patient whose camptocormia was levodopa responsive. The bending angle was not a prognostic factor. Our data indicate that the main prognostic factor for a beneficial DBS effect on camptocormia is its short duration. As an explanation, we suggest that neurostimulation may improve camptocormia only as long as muscle pathology is limited. Our findings may help to elucidate the mode of action of neurostimulation. A prospective study is necessary.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.