Evidence map›Paper›PMID 25678264›Full record

ArticleJournal of thrombosis and haemostasis : JTH2015

Effects of airborne fine particles (PM2.5 ) on deep vein thrombosis admissions in the northeastern United States.

I Kloog, A Zanobetti, F Nordio, B A Coull, A A Baccarelli, J Schwartz

Open access · greenAbstract read
In one paragraph

Article in Journal of thrombosis and haemostasis : JTH, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 3 pooled it
4.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 3 syntheses or guidelines pooled it, 73 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Performance of fine particulate matter data on air quality in an epidemiological study in Salvador, Brazil.Revista brasileira de epidemiologia = Brazilian journal of epidemiology · 2024
    Article
  11. Article
  12. Associations between long-term exposures to airborne PMEnvironmental health : a global access science source · 2022
    Article
  13. Review
  14. Article
  15. Saharan Dust and Childhood Respiratory Symptoms in Benin.International journal of environmental research and public health · 2022
    Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

I KloogDepartment of Geography and Environmental Development, Ben-Gurion University of the Negev, Beer Sheva, Israel.
A Zanobetti
F Nordio
B A Coull
A A Baccarelli
J Schwartz
Harvard University · USBen-Gurion University of the Negev · IL

Funding

Translational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI JAIME ELIZABETH HART · 1985 to 2026
$44.6M
Epigenetic Mechanisms of PM-Mediated CVD RiskR01ES020836 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BACCARELLI, ANDREA, HOU, LIFANG · 2012 to 2016
$3.0M
Environment, Fetal Tissue DNA Methylation & BirthweightR01ES020268 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BACCARELLI, ANDREA, WRIGHT, ROBERT O · 2011 to 2013
$2.5M
NIEHS NIH HHS ES-000002NIEHS NIH HHS P30 ES000002NIEHS NIH HHS R01 ES020268NIEHS NIH HHS R01 ES020836
6 · The paper itself

Abstract

backgroundLiterature relating air pollution exposure to deep vein thrombosis (DVT) and pulmonary embolism (PE), despite biological plausibility, is sparse. No comprehensive study examining associations between both short- and long-term exposure to particulate matter (PM)2.5 and DVT or PE has been published. Using a novel PM2.5 prediction model, we study whether long- and short-term PM2.5 exposure is associated with DVT and PE admissions among elderly across the northeastern United States.

methodsWe estimated daily exposure of PM2.5 in each ZIP code. We investigated the long- and short-term effects of PM2.5 on DVT and PE hospital admissions. There were 453,413 DVT and 151,829 PE admissions in the study. For short-term exposure, we performed a case crossover analysis matching month and year and defined the hazard period as lag 01 (exposure of day of admission and previous day). For the long-term association, we used a Poisson regression.

resultsA 10-μg m(-3) increase in short-term exposure was associated with a 0.63% increase in DVT admissions (95% confidence interval [CI] = 0.03% to 1.25%) and a 6.98% (95% CI = 5.65% to 8.33%) increase in long-term exposure admissions. For PE, the associated risks were 0.38% (95% CI = -0.68% to 1.25%) and 2.67% (95% CI = 5.65% to 8.33%). These results persisted when analyses were restricted to location-periods meeting the current Environmental Protection Agency annual standard of 12 μg m(-3) .

conclusionsOur findings showed that PM2.5 exposure was associated with DVT and PE hospital admissions and that current standards are not protective of this result.

Indexed as

Patient AdmissionAgedEnvironmental ExposureFemaleHumansMaleNew EnglandParticulate MatterVenous ThrombosisParticulate Matterair pollutiondeep vein thrombosisenvironmentepidemiologypublic healthvenous thrombosis

Identifiers

PMID25678264
PMCPMC4424156
OpenAlexW2073489890

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.