ArticleMammalian genome : official journal of the International Mammalian Genome Society2015
Genome-wide association analysis reveals genetic loci and candidate genes for meat quality traits in Chinese Laiwu pigs.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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29 citing papers in PubMed, 52 citations in OpenAlex.
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- Expression Profile and Regulatory Properties of m6A-Modified circRNAs in the Longissimus Dorsi of Queshan Black and Large White Pigs.Animals : an open access journal from MDPI · 2023Article
- Genome-wide association study reveals genetic loci and candidate genes for meat quality traits in a four-way crossbred pig population.Frontiers in genetics · 2023Article
- The Genetic Architecture of Meat Quality Traits in a Crossbred Commercial Pig Population.Foods (Basel, Switzerland) · 2022Article
- Fine-mapping and identification of candidate causal genes for tail length in the Merinolandschaf breed.Communications biology · 2022Article
- An imputed whole-genome sequence-based GWAS approach pinpoints causal mutations for complex traits in a specific swine population.Science China. Life sciences · 2022Article
- Spatiotemporal Regulation and Functional Analysis of Circular RNAs in Skeletal Muscle and Subcutaneous Fat during Pig Growth.Biology · 2021Article
- Evidence for and localization of proposed causative variants in cattle and pig genomes.Genetics, selection, evolution : GSE · 2021Review
- Genome-Wide Association Study of Meat Quality Traits in a Three-Way Crossbred Commercial Pig Population.Frontiers in genetics · 2021Article
- An Integrative Analysis of Transcriptome and GWAS Data to Identify Potential Candidate Genes Influencing Meat Quality Traits in Pigs.Frontiers in genetics · 2021Article
- Are scurs in heterozygous polled (Pp) cattle a complex quantitative trait?Genetics, selection, evolution : GSE · 2020Article
- A functional regulatory variant of MYH3 influences muscle fiber-type composition and intramuscular fat content in pigs.PLoS genetics · 2019Article
- Data Mining and Validation of AMPK Pathway as a Novel Candidate Role Affecting Intramuscular Fat Content in Pigs.Animals : an open access journal from MDPI · 2019Article
- Landscape of Loci and Candidate Genes for Muscle Fatty Acid Composition in Pigs Revealed by Multiple Population Association Analysis.Frontiers in genetics · 2019Article
- Ectopic Overexpression of Porcine Myh1 Increased in Slow Muscle Fibers and Enhanced Endurance Exercise in Transgenic Mice.International journal of molecular sciences · 2018Article
- Genome-wide association study reveals genetic loci and candidate genes for average daily gain in Duroc pigs.Asian-Australasian journal of animal sciences · 2018Article
- Genome-wide profiling of Sus scrofa circular RNAs across nine organs and three developmental stages.DNA research : an international journal for rapid publication of reports on genes and genomes · 2017Article
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14 authors at 1 institution in 1 country.
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Abstract
Meat quality traits have economically significant impacts on the pig industry, and can be improved using molecular approaches in pig breeding. Since 1994 when the first genome-wide scan for quantitative trait loci (QTLs) in pig was reported, over the past two decades, numerous QTLs have been identified for meat quality traits by family based linkage analyses. However, little is known about the genetic variants for meat quality traits in Chinese purebred or outbred populations. To unveil it, we performed a genome-wide association study for 10 meat quality traits in Chinese purebred Laiwu pigs. In total, 75 significant SNPs (P < 1.01 × 10(-6)) and 33 suggestive SNPs (P < 2.03 × 10(-5)) were identified. On SSC12, a region between 56.22 and 61.49 Mb harbored a cluster of SNPs that were associated with meat color parameters (L*, lightness; a*, redness; b*, yellowness) and moisture content of longissimus muscle (LM) and semimembranosus muscle at the genome-wide significance level. A region on SSC4 also has pleiotropic effects on moisture content and drip loss of LM. In addition, this study revealed at least five novel QTLs and several candidate genes including 4-linked MYH genes (MYH1, MYH2, MYH3, and MYH13), MAL2, LPAR1, and PRKAG3 at four significant loci. Except for the SSC12 QTL, other QTLs are likely tissue-specific. These results provide new insights into the genetic basis of meat quality traits in Chinese Laiwu pigs and some significant SNPs reported here could be incorporated into the selection programs involving this breed.
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