Evidence map›Paper›PMID 25678143›Full record

Observational studyJournal of neurovirology2015

Patterns of peripheral neuropathy in ART-naïve patients initiating modern ART regimen.

Anthony J Lee, Ronald J Bosch, Scott R Evans, Kunling Wu, Taylor Harrison, Philip Grant, David B Clifford

Open access · greenAbstract readObservational Study
In one paragraph

Observational study in Journal of neurovirology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Dissociable Contributions of Precuneus and Cerebellum to Subjective and Objective Neuropathy in HIV.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2019
    Article
  3. Article
  4. Global HIV neurology: a comprehensive review.AIDS (London, England) · 2019
    Review
  5. High-Risk Prescription Opioid Use Among People Living With HIV.Journal of acquired immune deficiency syndromes (1999) · 2018
    Article
  6. Observational
  7. Article
  8. Update of HIV-Associated Sensory Neuropathies.Current treatment options in neurology · 2017
    Review
  9. Neurologic Complications in Treated HIV-1 Infection.Current neurology and neuroscience reports · 2016
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Anthony J LeeCenter for Biostatistics in AIDS Research, Department of Biostatistics, FXB 604B, Harvard School of Public Health, 651 Huntington Avenue, Boston, MA, 02115, USA, alee@sdac.harvard.edu.
Ronald J Bosch
Scott R Evans
Kunling Wu
Taylor Harrison
Philip Grant
David B Clifford
Harvard University · USCancer Research And Biostatistics · USEmory University · USStanford Medicine · USWashington University in St. Louis · US

Funding

Leadership and Operations Center (LOC), AIDS Clinical Trials Group (ACTG); LOC 1/UM1AI068636 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Joseph J Eron, RAJESH T GANDHI · 2011 to 2026
$1073.1M
Statistical and Data Management Center (SDMC), AIDS Clinical Trials Group (ACTG)UM1AI068634 · NIAID · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Marlene Ann Cooper, Michael David Hughes · 2011 to 2026
$246.6M
AIDS Clinical Trials Group NetworkU01AI068636 · NIAID · SOCIAL AND SCIENTIFIC SYSTEMS, INC. · PI KURITZKES, DANIEL R. · 2006 to 2010
$147.1M
Statistical and Data Management Center for the AIDS Clinical Trials GroupU01AI068634 · NIAID · HARVARD SCHOOL OF PUBLIC HEALTH · PI HUGHES, MICHAEL DAVID · 2006 to 2010
$71.9M
NEUROLOGIC AIDS RESEARCH CONSORTIUMU01NS032228 · NINDS · WASHINGTON UNIVERSITY · PI CLIFFORD, DAVID B · 2003 to 2008
$11.4M
NIMODIPINE AND MEMANTINE FOR THE NEUROLOGICAL MANIFESTATIONS OF HIV-1R01NS032228 · NINDS · WASHINGTON UNIVERSITY · PI GATSONIS, CONSTANTINE A. · 1997 to 2001
$2.7M
NIAID NIH HHS U01 AI068634NIAID NIH HHS U01 AI068636NIAID NIH HHS U01AI068636NIAID NIH HHS UM1 AI068634NIAID NIH HHS UM1 AI068636NINDS NIH HHS NS32228NINDS NIH HHS R01 NS032228NINDS NIH HHS U01 NS032228PHS HHS 1 U01 068634
6 · The paper itself

Abstract

The purpose of this study was to evaluate associations of pre-ART CD4 with peripheral neuropathy (PN) and estimate the prevalence of PN in HIV-positive patients starting modern combination antiretroviral therapy (cART) regimens. ART-naïve subjects initiating cART were followed longitudinally and screened for signs/symptoms of PN. Lower pre-ART CD4 count was associated with post-ART PN. After 7 years (n = 117), the prevalence (95% CI) of PN and SPN were 31% (23, 40%) and 5% (2, 11%) with pre-ART CD4 count >250 copies/μL. PN continues to be identified in HIV-infected individuals on modern cART by targeted assessment but is generally without symptoms.

Indexed as

HIV InfectionsPeripheral Nervous System DiseasesAnti-HIV AgentsCD4 Lymphocyte CountFemaleHumansMaleMiddle AgedYoung AdultAnti-HIV Agents

Identifiers

PMID25678143
PMCPMC4624403
OpenAlexW2090851771

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.