Trial reportOncology2015
Cognitive impairment after chemotherapy related to atypical network architecture for executive control.
Trial report in Oncology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Cognitive Training for Adults With Bothersome Tinnitus: A Randomized Clinical Trial.JAMA otolaryngology-- head & neck surgery · 2017Trial
- Mapping Cognitive Oncology: A Decade of Trends and Research Fronts.Medical sciences (Basel, Switzerland) · 2025Review
- Article
- Cancer-related cognitive impairment in racial and ethnic minority groups: a scoping review.Journal of cancer research and clinical oncology · 2023Article
- Dynamic functional network connectivity reveals the brain functional alterations in lung cancer patients after chemotherapy.Brain imaging and behavior · 2022Article
- Altered regional homogeneity in patients with ovarian cancer treated with chemotherapy: a resting state fMRI study.Brain imaging and behavior · 2022Article
- Four decades of chemotherapy-induced cognitive dysfunction: comprehensive review of clinical, animal and in vitro studies, and insights of key initiating events.Archives of toxicology · 2022Review
- Comparison of functional dorsal attention network alterations in breast cancer survivors before and after chemotherapy.Medicine · 2021Article
- Increased resting-state cerebellar-cortical connectivity in breast cancer survivors with cognitive complaints after chemotherapy.Scientific reports · 2021Article
- Case Report: Disruption of Resting-State Networks and Cognitive Deficits After Whole Brain Irradiation for Singular Brain Metastasis.Frontiers in neuroscience · 2021Article
- Network-level functional connectivity alterations in chemotherapy treated breast cancer patients: a longitudinal resting state functional MRI study.Cancer imaging : the official publication of the International Cancer Imaging Society · 2020Article
- Aberrant static and dynamic functional connectivity of the executive control network in lung cancer patients after chemotherapy: a longitudinal fMRI study.Brain imaging and behavior · 2020Article
- Modulation of Interhemispheric Functional Coordination in Breast Cancer Patients Receiving Chemotherapy.Frontiers in psychology · 2020Article
- Late Effects of Breast Cancer Treatment and Outcome after Corrective Interventions.Asian Pacific journal of cancer prevention : APJCP · 2019Article
- Association of functional dorsal attention network alterations with breast cancer and chemotherapy.Scientific reports · 2019Article
- Neural correlates of chemotherapy-induced emotion regulation impairment in breast cancer patients.American journal of cancer research · 2019Article
- Peroxisomes contribute to oxidative stress in neurons during doxorubicin-based chemotherapy.Molecular and cellular neurosciences · 2018Article
- A systemic literature review of neuroimaging studies in women with breast cancer treated with adjuvant chemotherapy.Contemporary oncology (Poznan, Poland) · 2017Review
- TFEB ameliorates the impairment of the autophagy-lysosome pathway in neurons induced by doxorubicin.Aging · 2016Article
- Neurotoxic Effects of Anthracycline- vs Nonanthracycline-Based Chemotherapy on Cognition in Breast Cancer Survivors.JAMA oncology · 2016Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
objectivesA common complaint of cancer patients is the experience of cognitive difficulty during and after chemotherapy. We hypothesized that cognitive impairment may result from dysfunction in large-scale brain networks, particularly those involved in attentional control.
methodsUsing a case-control design, this study includes women with a history of invasive ductal or lobular triple-negative breast cancer who completed standard adjuvant chemotherapy within 2 years of study entry. Women who reported cognitive impairment by the Global Rating of Cognition question were considered to be cases (n = 15). Women who reported no cognitive impairment were considered to be controls (n = 13). All enrolled participants were eligible for MRI investigation and underwent resting-state functional connectivity MRI.
resultsWomen who self-reported cognitive impairment were found to have disrupted resting-state functional connectivity, as measured by MRI, when compared to women who did not self-report cognitive impairment. These findings suggest that some women may be more sensitive to the standard treatments for breast cancer and that this increased sensitivity may result in functional connectivity alterations in the brain networks supporting attention and executive function.
conclusionsNeuroimaging analyses confirmed self-reported cognitive deficits in women with breast cancer treated with chemotherapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.