Evidence map›Paper›PMID 25678001›Full record

ReviewClinics in perinatology2015

Infectious causes of necrotizing enterocolitis.

Sarah A Coggins, James L Wynn, Jörn-Hendrik Weitkamp

Abstract readReview
In one paragraph

Review in Clinics in perinatology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
74citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

74 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Diagnosis of infected pancreatic necrosis: A review of the role of blood biomarkers.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2025
    Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Intrauterine Shaping of Fetal Microbiota.Journal of clinical medicine · 2024
    Review
  16. Review
  17. Article
  18. Article
  19. Review
  20. Article

14 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Sarah A CogginsVanderbilt University School of Medicine, 2215 Garland Avenue, Nashville, TN 37232, USA.
James L WynnDepartment of Pediatrics, Monroe Carell Jr. Children's Hospital at Vanderbilt, Vanderbilt University, 2215 B Garland Avenue, 1125 MRB IV/Light Hall, Nashville, TN 37232, USA.
Jörn-Hendrik WeitkampDepartment of Pediatrics, Monroe Carell Jr. Children's Hospital at Vanderbilt, Vanderbilt University, 2215 B Garland Avenue, 1125 MRB IV/Light Hall, Nashville, TN 37232, USA. Electronic address: hendrik.weitkamp@vanderbilt.edu.

Funding

The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
Translational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICHARD M. PEEK · 2002 to 2026
$29.9M
The Role of the Inflammasome in Neonatal SepsisK08GM106143 · NIGMS · VANDERBILT UNIVERSITY · PI WYNN, JAMES LAWRENCE · 2013 to 2017
$875k
Development of Intestinal Immune Regulation in Human InfantsK08HD061607 · NICHD · VANDERBILT UNIVERSITY · PI WEITKAMP, JOERN-HENDRIK · 2009 to 2013
$628k
NCATS NIH HHS UL1 TR000445NICHD NIH HHS K08 HD061607NIDDK NIH HHS P30 DK058404NIGMS NIH HHS K08 GM106143
6 · The paper itself

Abstract

Necrotizing enterocolitis (NEC) is the most common gastrointestinal emergency among premature infants. Although a large body of research has focused on understanding its pathogenesis, the exact mechanism has not been elucidated. Of particular interest is the potential causative role of infectious culprits in the development of NEC. A variety of reports describe bacterial, viral, and fungal infections occurring in association with NEC; however, no single organism has emerged as being definitively involved in NEC pathogenesis. In this review, the authors summarize the literature on infectious causes of NEC.

Indexed as

Bacterial InfectionsCandidiasisEnterocolitis, NecrotizingHumansInfantInfant, NewbornInfant, PrematureVirus DiseasesBacteriaFungiNecrotizing enterocolitisNeonateVirus

Identifiers

PMID25678001
PMCPMC4328138

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.