Evidence map›Paper›PMID 25677995›Full record

ReviewClinics in perinatology2015

Bacterial meningitis in infants.

Lawrence C Ku, Kim A Boggess, Michael Cohen-Wolkowiez

Open access · greenAbstract readReview
In one paragraph

Review in Clinics in perinatology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 125 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
125citing papers in PubMed, 4 pooled it
4.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

125 citing papers in PubMed, 4 syntheses or guidelines pooled it, 263 citations in OpenAlex.

  1. Pooled it
  2. Systematic review and meta-analysis of intraventricular antibiotics for neonatal meningitis and ventriculitis.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024
    Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Late-Onset Meningitis due toClinical case reports · 2026
    Article
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  12. Review
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  15. Duration of Antibiotic Therapy forThe journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2026
    Article
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  17. Article
  18. Article
  19. Article
  20. Article

65 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Lawrence C KuDepartment of Pediatrics, Duke Clinical Research Institute, Box 17969, Durham, NC 27715, USA.
Kim A BoggessDepartment of Obstetrics & Gynecology, University of North Carolina School of Medicine, CB 7570, Chapel Hill, NC 27599-7570, USA.
Michael Cohen-WolkowiezDepartment of Pediatrics, Duke Clinical Research Institute, Box 17969, Durham, NC 27715, USA. Electronic address: michael.cohenwolkowiez@duke.edu.
Clinical Research Institute · USUniversity of North Carolina at Chapel Hill · US

Funding

Re-Entry Supplement: Investigation of Oral Microbial Enzymes for the Detection and Treatment of Periodontal DiseaseUL1TR002489 · NCATS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BUSE, JOHN BERNARD, SHAHEEN, NICHOLAS J · 2018 to 2022
$48.6M
North Carolina Translational & Clinical Sciences Institute (NC TraCS)UL1TR001111 · NCATS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BUSE, JOHN BERNARD, CAREY, TIMOTHY S · 2013 to 2017
$43.9M
Duke CTSA (Composite)UL1TR001117 · NCATS · DUKE UNIVERSITY · PI BOULWARE, LEIGH E, LI, JENNIFER S · 2013 to 2017
$41.3M
UNC BIRCWH CAREER DEVELOPMENT PROGRAMK12HD001441 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BOGGESS, KIM A · 2000 to 2019
$9.3M
UNC-Duke Collaborative Clinical Pharmacology Postdoctoral Training Program-Evaluation SupplementT32GM086330 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KIM L.R. BROUWER, Daniel Gonzalez · 2011 to 2026
$8.5M
Center for Molecular &Cellular Studies of Ped DiseaseK12HD043494 · NICHD · DUKE UNIVERSITY · PI REED, ANN M. · 2003 to 2017
$5.2M
Training in Epidemiology and Clinical Trials (TECT)T32HD040672 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BOGGESS, KIM A · 2001 to 2015
$4.2M
Cesarean Section Optimal Antibiotic Prophylaxis (C/SOAP) TrialR01HD064729 · NICHD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI TITA, ALAN THEVENET N. · 2010 to 2013
$2.8M
Clinical Practice Data to Aid Narrow Therapeutic Index Drug ClassificationU01FD004858 · FDA · DUKE UNIVERSITY · PI COHEN-WOLKOWIEZ, MICHAEL · 2013 to 2014
$497k
FDA HHS 1U01FD004858-01FDA HHS U01 FD004858NCATS NIH HHS 1UL1TR001111NCATS NIH HHS UL1 TR001111NCATS NIH HHS UL1 TR001117NCATS NIH HHS UL1TR001117NCATS NIH HHS UL1 TR002489NICHD NIH HHS 1R01HD064729-01A1NICHD NIH HHS 5K12HD001441NICHD NIH HHS 5T32HD040672-13NICHD NIH HHS K12 HD001441NICHD NIH HHS K12 HD043494NICHD NIH HHS R01 HD064729NICHD NIH HHS T32 HD040672NIGMS NIH HHS 5T32GM086330-03NIGMS NIH HHS T32 GM086330
6 · The paper itself

Abstract

Neonatal bacterial meningitis is uncommon but devastating. Morbidity among survivors remains high. The types and distribution of pathogens are related to gestational age, postnatal age, and geographic region. Confirming the diagnosis is difficult. Clinical signs are often subtle, lumbar punctures are frequently deferred, and cerebrospinal fluid (CSF) cultures can be compromised by prior antibiotic exposure. Infants with bacterial meningitis can have negative blood cultures and normal CSF parameters. Promising tests such as the polymerase chain reaction require further study. Prompt treatment with antibiotics is essential. Clinical trials investigating a vaccine for preventing neonatal Group B Streptococcus infections are ongoing.

Indexed as

Anti-Bacterial AgentsBacterial VaccinesCulture TechniquesEscherichia coli InfectionsGestational AgeHumansInfantInfant, NewbornInfant, Very Low Birth WeightMeningitis, BacterialSpinal PunctureStreptococcal InfectionsStreptococcus agalactiaeAnti-Bacterial AgentsBacterial VaccinesAntibioticsCerebrospinal fluidLumbar punctureNeonatal bacterial meningitisVaccineVery low birth weight

Identifiers

PMID25677995
PMCPMC4332563
OpenAlexW2038254536

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.