Evidence map›Paper›PMID 25677806›Full record

ArticleMolecular oncology2015

RhoC and ROCKs regulate cancer cell interactions with endothelial cells.

Nicolas Reymond, Jae Hong Im, Ritu Garg, Susan Cox, Magali Soyer, Philippe Riou, Audrey Colomba, Ruth J Muschel, Anne J Ridley

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular oncology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 30 citations in OpenAlex.

  1. Review
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  3. CircRNA-regulated glucose metabolism in ovarian cancer: an emerging landscape for therapeutic intervention.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Nicolas ReymondKing's College London, Randall Division of Cell and Molecular Biophysics, New Hunt's, House, Guy's Campus, London SE1 1UL, UK.
Jae Hong ImGray Institute for Radiation Oncology and Biology, University of Oxford, Oxford OX3 7IJ, England, UK.
Ritu GargKing's College London, Randall Division of Cell and Molecular Biophysics, New Hunt's, House, Guy's Campus, London SE1 1UL, UK.
Susan CoxKing's College London, Randall Division of Cell and Molecular Biophysics, New Hunt's, House, Guy's Campus, London SE1 1UL, UK.
Magali SoyerKing's College London, Randall Division of Cell and Molecular Biophysics, New Hunt's, House, Guy's Campus, London SE1 1UL, UK.
Philippe RiouKing's College London, Randall Division of Cell and Molecular Biophysics, New Hunt's, House, Guy's Campus, London SE1 1UL, UK.
Audrey ColombaKing's College London, Randall Division of Cell and Molecular Biophysics, New Hunt's, House, Guy's Campus, London SE1 1UL, UK.
Ruth J MuschelGray Institute for Radiation Oncology and Biology, University of Oxford, Oxford OX3 7IJ, England, UK.
Anne J RidleyKing's College London, Randall Division of Cell and Molecular Biophysics, New Hunt's, House, Guy's Campus, London SE1 1UL, UK. Electronic address: anne.ridley@kcl.ac.uk.
King's College London · GBCRUK/MRC Oxford Institute for Radiation Oncology · GBUniversity of Oxford · GB

Funding

Biotechnology and Biological Sciences Research Council BB/E004083/2Cancer Research UK 15961Cancer Research UK 20407Worldwide Cancer Research 11-0674
6 · The paper itself

Abstract

RhoC is a member of the Rho GTPase family that is implicated in cancer progression by stimulating cancer cell invasiveness. Here we report that RhoC regulates the interaction of cancer cells with vascular endothelial cells (ECs), a crucial step in the metastatic process. RhoC depletion by RNAi reduces PC3 prostate cancer cell adhesion to ECs, intercalation between ECs as well as transendothelial migration in vitro. Depletion of the kinases ROCK1 and ROCK2, two known RhoC downstream effectors, similarly decreases cancer interaction with ECs. RhoC also regulates the extension of protrusions made by cancer cells on vascular ECs in vivo. Transient RhoC depletion is sufficient to reduce both early PC3 cell retention in the lungs and experimental metastasis formation in vivo. Our results indicate RhoC plays a central role in cancer cell interaction with vascular ECs, which is a critical event for cancer progression.

Indexed as

Cell CommunicationCell Line, TumorHumansHuman Umbilical Vein Endothelial CellsNeoplasmsrho-Associated KinasesrhoC GTP-Binding Proteinrho GTP-Binding Proteinsrho-Associated KinasesrhoC GTP-Binding ProteinRHOC protein, humanrho GTP-Binding ProteinsROCK1 protein, humanROCK2 protein, humancancer metastasiscell migrationEndothelial cellsRhoCRho GTPasesROCKs

Identifiers

PMID25677806
PMCPMC4449123
OpenAlexW2038165112

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.