Evidence map›Paper›PMID 25677705›Full record

ReviewInfectious disease clinics of North America2015

Fecal microbiota transplantation for the management of Clostridium difficile infection.

Krishna Rao, Vincent B Young

Abstract readReview
In one paragraph

Review in Infectious disease clinics of North America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Tobramycin Nanoantibiotics and Their Advantages: A Minireview.International journal of molecular sciences · 2022
    Review
  6. In Vitro and In Vivo Anti-Journal of microbiology and biotechnology · 2022
    Article
  7. Successful use of early, repeat fecal microbiota transplantation for initial treatment of severe, refractory Clostridioides difficile colitis.American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists · 2021
    Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. A probiotic yeast-based immunotherapy againstScience translational medicine · 2020
    Article
  13. Chronic Inflammatory Diseases: Are We Ready for Microbiota-based Dietary Intervention?Cellular and molecular gastroenterology and hepatology · 2019
    Review
  14. Review
  15. Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Krishna RaoDivision of Infectious Diseases, Department of Internal Medicine, University of Michigan School of Medicine, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA; Division of Infectious Diseases, Department of Internal Medicine, Veterans Affairs Ann Arbor Healthcare System, 2215 Fuller Road, Ann Arbor, MI 48105, USA.
Vincent B YoungDivision of Infectious Diseases, Department of Internal Medicine, University of Michigan School of Medicine, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA; Department of Microbiology and Immunology, University of Michigan School of Medicine, 1150 West Medical Center Drive, Ann Arbor, MI 48109, USA. Electronic address: youngvi@umich.edu.

Funding

Michigan Institute for Clinical and Health Research (MCHR)UL1TR000433 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MASHOUR, GEORGE ALEXANDER · 2012 to 2016
$49.9M
Research Education CoreP30AG024824 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Neil Alexander · 2004 to 2026
$29.2M
University of Michigan Center for Gastrointestinal ResearchP30DK034933 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI OWYANG, CHUNG · 1986 to 2021
$22.5M
The Interplay Between Host Immunity and Clostridium difficile PathogenesisU19AI090871 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI YOUNG, VINCENT B · 2010 to 2014
$7.5M
Impacts of Molecular Oxygen on the Structure and Function of the Intestinal MicroR01GM099549 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GRATE, JAY W, SCHMIDT, THOMAS M · 2013 to 2016
$1.1M
NCATS NIH HHS 2UL1TR000433NCATS NIH HHS UL1 TR000433NIAID NIH HHS U19 AI090871NIAID NIH HHS U19-AI090871NIA NIH HHS AG-024824NIA NIH HHS P30 AG024824NIDDK NIH HHS P30 DK034933NIGMS NIH HHS R01 GM099549
6 · The paper itself

Abstract

This article discusses the use of fecal microbiota transplantation (FMT) for the treatment of recurrent Clostridium difficile infection (CDI). The disruption of the normal gut microbiota is central to the pathogenesis of CDI, and disruption persists in recurrent disease. The use of FMT for recurrent CDI is characterized by a high response rate and short term safety is excellent, although the long-term effects of FMT are as yet unknown.

Indexed as

Clostridioides difficileBiological TherapyClostridium InfectionsDisease ManagementFecesGastrointestinal TractHumansIntestinal DiseasesMicrobiotaClostridium difficileColitisFecal microbiota transplantationMicrobiomeNonantibiotic treatmentRecurrent C difficile infection

Identifiers

PMID25677705
PMCPMC4328137

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.