ArticlePhysiological reports2015
Activation of the habenula complex evokes autonomic physiological responses similar to those associated with emotional stress.
Article in Physiological reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 42 citations in OpenAlex.
- Article
- The Neuroanatomy of the Habenular Complex and Its Role in the Regulation of Affective Behaviors.Journal of functional morphology and kinesiology · 2024Review
- The dopaminergic system mediates the lateral habenula-induced autonomic cardiovascular responses.Frontiers in physiology · 2024Article
- Chronic social stress blunts core body temperature and molecular rhythms ofOpen biology · 2023Article
- PACAP-expressing neurons in the lateral habenula diminish negative emotional valence.Genes, brain, and behavior · 2022Article
- Lateral habenula neurocircuits mediate the maternal disruptive effect of maternal stress: A hypothesis.Zoological research · 2022Review
- The omnipresence of autonomic modulation in health and disease.Progress in neurobiology · 2022Review
- Habenula bibliometrics: Thematic development and research fronts of a resurgent field.Frontiers in integrative neuroscience · 2022Article
- Lateral Habenula Regulates Cardiovascular Autonomic ResponsesFrontiers in neuroscience · 2021Article
- Stress induces divergent gene expression among lateral habenula efferent pathways.Neurobiology of stress · 2020Article
- Activating dopamine D2 receptors reduces brown adipose tissue thermogenesis induced by psychological stress and by activation of the lateral habenula.Scientific reports · 2019Article
- The Lateral Habenula Directs Coping Styles Under Conditions of Stress via Recruitment of the Endocannabinoid System.Biological psychiatry · 2018Article
- Clozapine, chlorpromazine and risperidone dose-dependently reduce emotional hyperthermia, a biological marker of salience.Psychopharmacology · 2017Article
- Lateral habenula regulation of emotional hyperthermia: mediation via the medullary raphé.Scientific reports · 2017Article
- Engaging Research Domain Criteria (RDoC): Neurocircuitry in Search of Meaning.Schizophrenia bulletin · 2016Review
- Central control of body temperature.F1000Research · 2016Review
- Psychogenic fever: how psychological stress affects body temperature in the clinical population.Temperature (Austin, Tex.)Review
- Control of cutaneous blood flow by central nervous system.Temperature (Austin, Tex.)Review
- Neural circuit for psychological stress-induced hyperthermia.Temperature (Austin, Tex.)Review
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neurons in the lateral habenula (LHb) discharge when an animal anticipates an aversive outcome or when an expected reward is not forthcoming, contributing to the behavioral response to aversive situations. So far, there is little information as to whether the LHb also contributes to autonomic physiological responses, including increases in body temperature (emotional hyperthermia) that are integrated with defensive behaviors. Vasoconstriction in cutaneous vascular bed and heat production in brown adipose tissue (BAT) both contribute to emotional hyperthermia. Our present study determines whether stimulation of the LHb elicits constriction of the tail artery and BAT thermogenesis in anesthetized Sprague-Dawley rats. Disinhibition of neurons in LHb with focal microinjections of bicuculline (1 nmol in 100 nl, bilaterally) acutely increased BAT temperature (+0.6 ± 0.1°C, n = 9 rats, P < 0.01) and reduced tail artery blood flow (by 88 ± 4%, n = 9 rats, P < 0.01). Falls in mesenteric blood flow, simultaneously recorded, were much less intense. The pattern of BAT thermogenesis and cutaneous vasoconstriction elicited by stimulating the habenula is similar to the pattern observed during stress-induced emotional hyperthermia, suggesting that the habenula may be important in this response.
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