Evidence map›Paper›PMID 25677463›Full record

ReviewJournal of neurology, neurosurgery, and psychiatry2015

Chronic inflammatory demyelinating polyradiculoneuropathy: from pathology to phenotype.

Emily K Mathey, Susanna B Park, Richard A C Hughes, John D Pollard, Patricia J Armati, Michael H Barnett, Bruce V Taylor, P James B Dyck, Matthew C Kiernan, Cindy S-Y Lin

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of neurology, neurosurgery, and psychiatry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 185 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
185citing papers in PubMed, 4 pooled it
28.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

185 citing papers in PubMed, 4 syntheses or guidelines pooled it, 417 citations in OpenAlex.

  1. Pooled it
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  8. Efficacy and safety of IVIG in CIDP: Combined data of the PRIMA and PATH studies.Journal of the peripheral nervous system : JPNS · 2019
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125 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 3 countries.

Emily K MatheyBrain and Mind Research Institute, University of Sydney, Sydney, New South Wales, Australia.
Susanna B ParkBrain and Mind Research Institute, University of Sydney, Sydney, New South Wales, Australia Neuroscience Research Australia & Prince of Wales Clinical School, University of New South Wales, Randwick, New South Wales, Australia.
Richard A C HughesMRC Centre for Neuromuscular Diseases, Institute of Neurology, University College London, London, UK.
John D PollardBrain and Mind Research Institute, University of Sydney, Sydney, New South Wales, Australia.
Patricia J ArmatiBrain and Mind Research Institute, University of Sydney, Sydney, New South Wales, Australia.
Michael H BarnettBrain and Mind Research Institute, University of Sydney, Sydney, New South Wales, Australia.
Bruce V TaylorMenzies Research Institute, University of Tasmania, Sydney, New South Wales, Australia.
P James B DyckDepartment of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
Matthew C KiernanBrain and Mind Research Institute, University of Sydney, Sydney, New South Wales, Australia.
Cindy S-Y LinFaculty of Medicine, Department of Physiology, Translational Neuroscience Facility, School of Medical Sciences, University of New South Wales, Randwick, New South Wales, Australia.
MIND Research Institute · USUniversity of Sydney · AUUniversity College London · GBUniversity of Tasmania · AUUNSW Sydney · AUWinnMed · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an inflammatory neuropathy, classically characterised by a slowly progressive onset and symmetrical, sensorimotor involvement. However, there are many phenotypic variants, suggesting that CIDP may not be a discrete disease entity but rather a spectrum of related conditions. While the abiding theory of CIDP pathogenesis is that cell-mediated and humoral mechanisms act together in an aberrant immune response to cause damage to peripheral nerves, the relative contributions of T cell and autoantibody responses remain largely undefined. In animal models of spontaneous inflammatory neuropathy, T cell responses to defined myelin antigens are responsible. In other human inflammatory neuropathies, there is evidence of antibody responses to Schwann cell, compact myelin or nodal antigens. In this review, the roles of the cellular and humoral immune systems in the pathogenesis of CIDP will be discussed. In time, it is anticipated that delineation of clinical phenotypes and the underlying disease mechanisms might help guide diagnostic and individualised treatment strategies for CIDP.

Indexed as

HumansMyelin SheathPhenotypePolyradiculoneuropathy, Chronic Inflammatory DemyelinatingSchwann CellsT-LymphocytesMYELINNEUROIMMUNOLOGYNEUROPATHYNEUROPHYSIOLOGYSCHWANN CELL

Identifiers

PMID25677463
PMCPMC4552934
OpenAlexW2110199093

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.