ArticleGenesis (New York, N.Y. : 2000)
Development of the zebrafish mesonephros.
Article in Genesis (New York, N.Y. : 2000). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 55 citations in OpenAlex.
- Mouse Mesonephros Promotes Differentiation of Oogonial Stem Cells into Follicle-like Structures via the PI3K/AKT Signaling Pathway.International journal of molecular sciences · 2026Article
- Whole-body single-cell atlas of an adult vertebrate in homeostasis and regeneration.bioRxiv : the preprint server for biology · 2026Article
- ift140 -Deficient Zebrafish as a Model for Kidney Cystogenesis and an F0-Based Screen for Genetic Modifiers of Kidney Cysts.Journal of the American Society of Nephrology : JASN · 2026Article
- [Inhibition of ferroptosis alleviates acute kidney injury caused by diquat in zebrafish].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2025Article
- Somites are a source of nephron progenitors in zebrafish.Nature communications · 2025Article
- Postembryonic Maintenance of Nephron Progenitor Cells with Low Translational Activity in the Chondrichthyan Scyliorhinus canicula.Journal of the American Society of Nephrology : JASN · 2025Article
- Comparative analysis ofbioRxiv : the preprint server for biology · 2025Article
- (Zebra)fishing for nephrogenesis genes.Tissue barriers · 2024Review
- SMAD2/3 signaling regulates initiation of mouse Wolffian ducts and proximal differentiation in Müllerian ducts.FEBS open bio · 2024Article
- Analysis of the distal urinary tract in larval and adult zebrafish reveals homology to the human system.Disease models & mechanisms · 2023Article
- Principles of Zebrafish Nephron Segment Development.Journal of developmental biology · 2023Review
- A comparative study of cellular diversity between the Xenopus pronephric and mouse metanephric nephron.Kidney international · 2023Article
- Kidney transcriptome and cystic kidney disease genes in zebrafish.Frontiers in physiology · 2023Article
- Article
- Comparative Studies of Renin-Null Zebrafish and Mice Provide New Functional Insights.Hypertension (Dallas, Tex. : 1979) · 2022Article
- Fibroblast growth factor signaling mediates progenitor cell aggregation and nephron regeneration in the adult zebrafish kidney.Developmental biology · 2019Article
- The Pronephros; a Fresh Perspective.Integrative and comparative biology · 2019Review
- Wnt signaling mediates new nephron formation during zebrafish kidney regeneration.Development (Cambridge, England) · 2019Article
- The role of macrophages during acute kidney injury: destruction and repair.Pediatric nephrology (Berlin, Germany) · 2019Review
- Investigating the RAS can be a fishy business: interdisciplinary opportunities using Zebrafish.Clinical science (London, England : 1979) · 2018Review
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
The vertebrate kidney plays an essential role in removing metabolic waste and balancing water and salt. This is carried out by nephrons, which comprise a blood filter attached to an epithelial tubule with proximal and distal segments. In zebrafish, two nephrons are first formed as part of the embryonic kidney (pronephros) and hundreds are formed later to make up the adult kidney (mesonephros). Previous studies have focused on the development of the pronephros while considerably less is known about how the mesonephros is formed. Here, we characterize mesonephros development in zebrafish and examine the nephrons that form during larval metamorphosis. These nephrons, arising from proliferating progenitor cells that express the renal transcription factor genes wt1b, pax2a, and lhx1a, form on top of the pronephric tubules and develop a segmentation pattern similar to pronephric nephrons. We find that the pronephros acts as a scaffold for the mesonephros, where new nephrons fuse with the distal segments of the pronephric tubules to form the final branching network that characterizes the adult zebrafish kidney.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.