Trial reportClinical oral investigations2015
Intraoral fluoride levels after use of conventional and high-fluoride dentifrices.
Trial report in Clinical oral investigations, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
In Vivo Evaluation of an Experimental Fluoride-containing Dentifrice With Hydrocolloid
Evaluation in Vivo of Experimental Dentifrice With Nanoencapsulated Fluoride
Evaluation in Vivo of Experimental Mouthwash With Nanoencapsulated Fluoride
Who cites it
13 citing papers in PubMed.
- Intraoral fluoride retention after using experimental toothpaste containing titanium tetrafluoride and chitosan.Clinical oral investigations · 2026Trial
- Diurnal and nocturnal salivary fluoride bioavailability following brushing with high- or regular-fluoride dentifrices.European journal of oral sciences · 2026Trial
- Understanding the variation in salivary fluoride levels: A secondary trajectory-based analysis of trial data.European journal of oral sciences · 2025Trial
- Fluoride Retention in Nocturnal Salivary Sediment After Use of a 5000 ppm F Dentifrice: A Randomized Crossover Clinical Trial.TheScientificWorldJournal · 2025Trial
- Randomized investigation of the bioavailability of fluoride in saliva after administration of sodium fluoride, amine fluoride and fluoride containing bioactive glass dentifrices.BMC oral health · 2019Trial
- A randomized triple-blind crossover trial of a hydrocolloid-containing dentifrice as a controlled-release system for fluoride.Clinical oral investigations · 2018Trial
- Fluoride in saliva and dental biofilm after 1500 and 5000 ppm fluoride exposure.Clinical oral investigations · 2018Trial
- Effects of pH and fluoride concentration of dentifrices on fluoride levels in saliva, biofilm, and biofilm fluid in vivo.Clinical oral investigations · 2016Trial
- Retention of fluoride in the oral cavity: A randomized clinical study with nanoencapsulated fluoride toothpaste.Journal of clinical and experimental dentistry · 2026Review
- Nocturnal Salivary Fluoride Bioavailability After Brushing with a High-fluoride Dentifrice.Biological trace element research · 2022Article
- Effect of high-fluoride dentifrice and bracket bonding composite material on enamel demineralization in situ.Clinical oral investigations · 2020Article
- Plaque Fluoride Levels as a Predictor of Caries Development in Early Childhood with High Sugar Exposure - A Preliminary Study.Clinical, cosmetic and investigational dentistry · 2020Article
- Fluoride Release of Fresh and Aged Glass Ionomer Cements after Recharging with High-Fluoride Dentifrice.International journal of dentistry · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThis study aimed to evaluate saliva and plaque as indicators of intraoral fluoride (F) levels after the use of conventional and high-fluoride dentifrices. MATERIALS AND
methodsSubjects were randomly assigned to brush their teeth with conventional (1000 ppm F), high-fluoride (5000 ppm F), and placebo dentifrices (fluoride free) for 10 days, following a double-blind, crossover protocol. Saliva and plaque samples were collected on the morning of the 5(th) and 10th days, respectively at 1 and 12 h after brushing, and analyzed with an ion-selective electrode after HMDS-facilitated diffusion. Data were analyzed by two-way repeated measures ANOVA, Tukey's test and Spearman's correlation coefficient (p < 0.05).
resultsPlaque and salivary F levels were significantly increased after the use of conventional and high-fluoride dentifrices when compared to values obtained for placebo, except plaque 12 h after the use of conventional dentifrice. A positive and significant correlation was found between fluoride concentrations in plaque and saliva for both times of sample collection.
conclusionBoth indicators assessed were able to detect significant differences among treatments and between times after brushing. The use of a high-fluoride dentifrice is able to significantly increase intraoral fluoride levels throughout the day, being therefore a useful therapy for patients at high caries risk. CLINICAL RELEVANCE: A dentifrice with high fluoride concentration could be regarded as a useful therapy of F delivery for high caries-risk patients, since intraoral F levels were sustained throughout most of the day after using this formulation.
Indexed as
Identifiers
25677244What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.