ArticleInternational journal of cancer2015
Alcohol intake and breast cancer in the European prospective investigation into cancer and nutrition.
Article in International journal of cancer, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 5 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
48 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Association between alcohol consumption and breast cancer incidence and prognosis: A systematic review and meta-analysis.Breast (Edinburgh, Scotland) · 2026Pooled it
- Pooled it
- Relationship between particulate matter exposure and female breast cancer incidence and mortality: a systematic review and meta-analysis.International archives of occupational and environmental health · 2021Pooled it
- Perspective: The Role of Beverages as a Source of Nutrients and Phytonutrients.Advances in nutrition (Bethesda, Md.) · 2020Pooled it
- Epigenome-wide association study for lifetime estrogen exposure identifies an epigenetic signature associated with breast cancer risk.Clinical epigenetics · 2019Pooled it
- Effect of daily alcohol intake on sex hormone levels among postmenopausal breast cancer survivors on aromatase inhibitor therapy: a randomized controlled crossover pilot study.Breast cancer research : BCR · 2025Trial
- Binge Drinking and Risk of Breast Cancer: Results from the SUN ('Seguimiento Universidad de Navarra') Project.Nutrients · 2020Trial
- Changes in alcohol consumption and the risk of postmenopausal breast cancer in the European Prospective Investigation into Cancer and Nutrition cohort.European journal of nutrition · 2026Article
- Influence of lifestyle factors on breast cancer incidence from mid-life to older age: an Australian longitudinal cohort study.BMJ open · 2026Article
- Mediterranean Diet and Agri-Food By-Products: A Possible Sustainable Approach for Breast Cancer Treatment.Antioxidants (Basel, Switzerland) · 2025Review
- Association between Urinary Phenols and Parabens as Well as Breast Cancer.Iranian journal of public health · 2025Article
- Metabolites in the Dance: Deciphering Gut-Microbiota-Mediated Metabolic Reprogramming of the Breast Tumor Microenvironment.Cancers · 2024Review
- Alcoholic beverage consumption and female breast cancer risk: A systematic review and meta-analysis of prospective cohort studies.Alcohol, clinical & experimental research · 2024Review
- Macronutrient composition of plant-based diets and breast cancer risk: the E3N prospective cohort study.European journal of nutrition · 2024Article
- Effects of ethanol or ethylene glycol exposure on PPARγ and aromatase expression in adipose tissue.Biochemistry and biophysics reports · 2024Article
- Impact of Alcohol Consumption on Breast Cancer Incidence and Mortality: The Women's Health Study.Journal of women's health (2002) · 2024Article
- Review
- Alcohol consumption and cancer incidence in women: interaction with smoking, body mass index and menopausal hormone therapy.BMC cancer · 2023Article
- Article
- The epidemiologic factors associated with breast density: A review.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2022Review
Corrections and comments
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Authors and funding
47 authors.
Funding
Abstract
Alcohol intake has been associated to breast cancer in pre and postmenopausal women; however results are inconclusive regarding tumor hormonal receptor status, and potential modifying factors like age at start drinking. Therefore, we investigated the relation between alcohol intake and the risk of breast cancer using prospective observational data from the European Prospective Investigation into Cancer and Nutrition (EPIC). Up to 334,850 women, aged 35-70 years at baseline, were recruited in ten European countries and followed up an average of 11 years. Alcohol intake at baseline and average lifetime alcohol intake were calculated from country-specific dietary and lifestyle questionnaires. The study outcomes were the Hazard ratios (HR) of developing breast cancer according to hormonal receptor status. During 3,670,439 person-years, 11,576 incident breast cancer cases were diagnosed. Alcohol intake was significantly related to breast cancer risk, for each 10 g/day increase in alcohol intake the HR increased by 4.2% (95% CI: 2.7-5.8%). Taking 0 to 5 g/day as reference, alcohol intake of >5 to 15 g/day was related to a 5.9% increase in breast cancer risk (95% CI: 1-11%). Significant increasing trends were observed between alcohol intake and ER+/PR+, ER-/PR-, HER2- and ER-/PR-HER2- tumors. Breast cancer risk was stronger among women who started drinking prior to first full-time pregnancy. Overall, our results confirm the association between alcohol intake and both hormone receptor positive and hormone receptor negative breast tumors, suggesting that timing of exposure to alcohol drinking may affect the risk. Therefore, women should be advised to control their alcohol consumption.
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