ArticleThe American journal of emergency medicine2015
Intravenous migraine therapy in children with posttraumatic headache in the ED.
Article in The American journal of emergency medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 3 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Current evidence for pharmacological management of pediatric concussion: a systematic review.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2023Pooled it
- Acute and chronic management of posttraumatic headache in children: A systematic review.Headache · 2021Pooled it
- Acute and preventive pharmacological treatment of post-traumatic headache: a systematic review.The journal of headache and pain · 2019Pooled it
- Randomized Study of Metoclopramide Plus Diphenhydramine for Acute Posttraumatic Headache.Neurology · 2021Trial
- An exploratory study of IV metoclopramide+diphenhydramine for acute post-traumatic headache.The American journal of emergency medicine · 2018Trial
- American Headache Society white paper on treatment of post-traumatic headache from concussion in youth.Headache · 2024Article
- Efficacy of outpatient infusion therapy in pediatric patients with postconcussive headaches.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2022Article
- Models for Treating Post-traumatic Headache.Current pain and headache reports · 2021Review
- Post-Traumatic Headache in Children and Adolescents: a Narrative Review with a Focus on Management.Current neurology and neuroscience reports · 2020Review
- Sleep Disorders and Their Management in Children With Ehlers-Danlos Syndrome Referred to Sleep Clinics.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2018Article
- Post-Traumatic Headache Therapy in the Athlete.Current pain and headache reports · 2016Review
- Pharmacologic Therapies for Pediatric Concussions.Sports healthReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundMore than 3.8 million children sustain traumatic brain injuries annually. Treatment of posttraumatic headache (PTH) in the emergency department (ED) is variable, and benefits are unclear.
objectiveThe objective of the study is to determine if intravenous migraine therapy reduces pain scores in children with PTH and factors associated with improved response.
methodsThis was a retrospective study of children, 8 to 21 years old, presenting to a tertiary pediatric ED with mild traumatic brain injury (mTBI) and PTH from November 2009 to June 2013. Inclusion criteria were mTBI (defined by diagnosis codes) within 14 days of ED visit, headache, and administration of one or more intravenous medications: ketorolac, prochlorperazine, metoclopramide, chlorpromazine, and ondansetron. Primary outcome was treatment success defined by greater than or equal to 50% pain score reduction during ED visit. Bivariate analysis and logistic regression were used to determine predictors of treatment success: age, sex, migraine or mTBI history, time since injury, ED head computed tomographic (CT) imaging, and pretreatment with oral analgesics.
resultsA total of 254 patients were included. Mean age was 13.8 years, 51% were female, 80% were white, mean time since injury was 2 days, and 114 patients had negative head CTs. Eighty-six percent of patients had treatment success with 52% experiencing complete resolution of headache. Bivariate analysis showed that patients who had a head CT were less likely to respond (80% vs 91%; P = .008).
conclusionsIntravenous migraine therapy reduces PTH pain scores for children presenting within 14 days after mTBI. Further prospective work is needed to determine long-term benefits of acute PTH treatment in the ED.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.